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Name | B1 bradykinin receptor |
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Species | Rattus norvegicus (Rat) |
Gene | Bdkrb1 |
Synonym | KB1 bradykinin receptor BKR1 BK-1 receptor B1R [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 337 |
Amino acid sequence | MASEVLLELQPSNRSLQAPANITSCESALEDWDLLYRVLPGFVITICFFGLLGNLLVLSFFLLPWRQWWWQQRQRQQRLTIAEIYLANLAASDLVFVLGLPFWAENIGNRFNWPFGTDLCRVVSGVIKANLFVSIFLVVAISQDRYRLLVYPMTSWGYRRRRQAQATCLLIWVAGGLLSIPTFLLRSVKVVPDLNVSACILLFPHEAWHFARMVELNVLGFLLPVTAIIFFNYHILASLRGQKEASRTRCGGPKGSKTTGLILTLVASFLVCWCPYHFFAFLDFLVQVRVIQDCSWKEITDLGLQLANFFAFVNSCLNPLIYVFAGRLLKTRVLGTL |
UniProt | P97583 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4613 |
IUPHAR | 41 |
DrugBank | N/A |
Name | CHEMBL313869 |
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Molecular formula | C41H66N12O10 |
IUPAC name | (2S)-2-[[(2S)-1-[(2S)-2-[[2-[[1-[[2-[[(2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]cycloheptanecarbonyl]amino]acetyl]amino]-3-hydroxypropanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid |
Molecular weight | 887.053 |
Hydrogen bond acceptor | 13 |
Hydrogen bond donor | 12 |
XlogP | -4.4 |
Synonyms | N/A |
Inchi Key | SZKSRADLWODSGY-QKUYTOGTSA-N |
Inchi ID | InChI=1S/C41H66N12O10/c42-19-9-6-14-27(43)34(57)50-28(15-10-20-46-40(44)45)35(58)47-24-33(56)52-41(17-7-1-2-8-18-41)39(63)48-23-32(55)49-30(25-54)37(60)53-21-11-16-31(53)36(59)51-29(38(61)62)22-26-12-4-3-5-13-26/h3-5,12-13,27-31,54H,1-2,6-11,14-25,42-43H2,(H,47,58)(H,48,63)(H,49,55)(H,50,57)(H,51,59)(H,52,56)(H,61,62)(H4,44,45,46)/t27-,28-,29-,30-,31-/m0/s1 |
PubChem CID | 10629523 |
ChEMBL | CHEMBL313869 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
pD2 | 5.4 - | PMID11170638 | ChEMBL |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218