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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Homo sapiens (Human)
Gene	HTR4
Synonym	5-HT-4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 5-HT4 receptor 5-HT4 serotonin receptor 4
Disease	N/A
Length	388
Amino acid sequence	MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDAVECGGQWESQCHPPATSPLVAAQPSDT
UniProt	Q13639
Protein Data Bank	N/A
GPCR-HGmod model	Q13639
3D structure model	This predicted structure model is from GPCR-EXP Q13639.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1875
IUPHAR	9
DrugBank	BE0000084

Ligand

Name	metoclopramide
Molecular formula	C14H22ClN3O2
IUPAC name	4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide
Molecular weight	299.799
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	2.6
Synonyms	Pramiel Primperan (TN) SBB037841 Spectrum4_000964 Tox21_110188 Metoclopramidum N-(Diethylaminoethyl)-2-methoxy-4-amino-5-chlorobenzamide NCGC00015643-07 Neu-Sensamide Parmid Gastrobid 4-Amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide; Methoxychloroprocainamide HMS2089G16 AB00053498-13 KBio2_002118 Apo-Metoclop KS-000048I1 Biomol-NT_000082 Maxeran (TN) BSPBio_000197 Metaclopromide CHEBI:107736 CS-1064 DivK1c_000069 364-62-5 Elieten (TN) 4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide (Mcp) Prestwick1_000209 Regla SCHEMBL18629 ST024773 Metoclopramide Monohydrochloride, Monohydrate UNII-L4YEB44I46 Metramid NCGC00015643-02 NCGC00015643-11 o-Anisamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)- Peraprin 4-amino-5-chloro-N-(2-diethylaminoethyl)-2-methoxybenzamide Gastrosil IDI1_000069 AC1L1HKD KBio3_001527 Benzamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxy- L4YEB44I46 BPBio1_001100 Maxolon (TN) C14H22ClN3O2 Methochlopramide cid_23659 D08VYV 2-Methoxy-4-amino-5-chloro-N,N-dimethylaminoethylbenzamide DSSTox_RID_80719 4-Amino-5-chloro-2-methoxy-N-(.beta.-diethylaminoethyl)benzamide Emperal Pms-Metoclopramide Primperan Reglan (TN) Spectrum2_001720 Metoclopramida Terperan Metoclopramide, European Pharmacopoeia (EP) Reference Standard ZINC1530716 Mygdalon NCGC00015643-05 NCGC00024440-04 o-Anisamide, 4-amino-5-chloro-N-[2-(diethylamino)ethyl]- Gastrese 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-benzamide;hydrochloride Gimoli 7232-21-5 (mono-hydrochloride) KB-189202 AKOS000280832 KM1470 Benzamide, 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy- LS-20038 BRD-K75641298-003-16-9 Megaldrate CCG-204847 Metochlopramide Clopra-Yellow (metaclopramide)4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide Degan (TN) EINECS 206-662-9 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-o-anisamide Pramin Pylomid (TN) SBI-0050740.P004 Spectrum5_001449 Metoclopramide (JP15/INN) Tox21_110188_1 Metoclopramidum [INN-Latin] n-Anisamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)- NCGC00015643-08 NINDS_000069 Paspertin 4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide (metoclopramide) Gastromax 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide;hydrochloride HSDB 7841 AB00053498_14 KBio2_004686 ARONIS24307 KS-5055 bmse000779 Maxolon BSPBio_002027 Metadrate CTK8G1095 2-methoxy-4-amino-5-chloro-N,N-(dimethylaminoethyl)benzamide DSSTox_CID_25169 364M625 Emetid Plasil Prestwick2_000209 Reglan SPBio_001740 ST077151 Metoclopramide Omega US9132134, Metoclopramide MolPort-000-883-854 NCGC00015643-03 NCGC00015643-13 o-Anisamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)- (8CI) 4-amino-5-chloro-N-[2-(diethylamino)-ethyl]-2-methoxybenzamide Gastrotablinen 5-Chloro-2-methoxyprocainamide Imperan AJ-26684 KBioGR_001307 Benzamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxy- (9CI) Lopac-M-0763 BRD-K75641298-001-01-5 MCULE-8566255889 CAS-364-62-5 Methoclopramide Clopra 2-Methoxy-5-chloroprocainamide DTXSID6045169 4-Amino-5-chloro-2-methoxy-N-(beta-diethylaminoethyl)benzamide Eucil Pramidin Primperan (tablet) (Salt/Mix) Reliveran Spectrum3_000504 Metoclopramida [INN-Spanish] Terperan (TN) Metoclopramide, VETRANAL(TM), analytical standard N-(2-diethylaminoethyl)-2-methoxy-4-amino-5-chlorobenzamide NCGC00015643-06 NCI60_003185 Octamide Gastro-Timelets 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxybenzamide GTPL241 AB00053498 KBio1_000069 AN-44542 KS-00000GNS Benzamide,4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy- Maxeran BRN 1884366 Metaclopramide Cerucal Metochloropramide Clopromate (metoclopramide)4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide DEL 1267 2576-84-3 (di-hydrochloride) Elieten 4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide Prestwick0_000209 Reclomide SC-81367 Spectrum_001638 Metoclopramide (JP17/INN) TTWJBBZEZQICBI-UHFFFAOYSA-N Metocobil NCGC00015643-01 NCGC00015643-09 Nu-Metoclopramide Paspertin (Salt/Mix) 4-Amino-5-chloro-N-(2-diethylamino-ethyl)-2-methoxy-benzamide(Metoclopramide) Gastronerton 4-azanyl-5-chloranyl-N-[2-(diethylamino)ethyl]-2-methoxy-benzamide;hydrochloride HY-17382 AB1009457 KBio2_007254 BDBM48320 L001078 BPBio1_000217 Maxolon (Salt/Mix) C07868 Metamide CHEMBL86 D00726 2-Methoxy-4-amino-5-chloro-N,N-dimethylaminoethyl)benzamide DSSTox_GSID_45169 4 Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide Emitasol Plasil (pharmaceutical) Prestwick3_000209 Reglan (Salt/Mix) SPBio_002118 Metoclol STL257058 Metoclopramide [INN:BAN:JAN] Z2196779550 Moriperan NCGC00015643-04 NCGC00024440-03 O-Anisamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-(8CI) FT-0628931 4-amino-5-chloro-N-[2-(diethylamino)ethyl]-2-methoxy-benzamide Gastrotem 54143-57-6 (mono-hydrochloride, mono-hydrate) J90028 AK468880 KBioSS_002118 Benzamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxy-(9CI) Lopac0_000762 BRD-K75641298-003-05-2 Meclopran CAS-7232-21-5 Methoxychlorprocainamide CLOPRA-"YELLOW" (4-amino-5-chloro-2-methoxyphenyl)-N-[2-(diethylamino)ethyl]carboxamide DB01233 232M215 Duraclamid 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide [ Show all ]
Inchi Key	TTWJBBZEZQICBI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C14H22ClN3O2/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3/h8-9H,4-7,16H2,1-3H3,(H,17,19)
PubChem CID	4168
ChEMBL	CHEMBL86
IUPHAR	241
BindingDB	48320
DrugBank	DB01233
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank
EC50	794.0 nM	N/A	BindingDB
EC50	794.33 nM	Bioorg. Med. Chem. Lett., (1994) 4:20:2477	ChEMBL
Intrinsic activity	0.5 -	Bioorg. Med. Chem. Lett., (1994) 4:20:2477	ChEMBL

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