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GPCR

NameLutropin-choriogonadotropic hormone receptor
SpeciesRattus norvegicus (Rat)
GeneLhcgr
SynonymLuteinizing hormone receptor
LSH-R
LHR
LH/CG-R
LH-R
[ Show all ]
DiseaseN/A for non-human GPCRs
Length700
Amino acid sequenceMGRRVPALRQLLVLAVLLLKPSQLQSRELSGSRCPEPCDCAPDGALRCPGPRAGLARLSLTYLPVKVIPSQAFRGLNEVVKIEISQSDSLERIEANAFDNLLNLSELLIQNTKNLLYIEPGAFTNLPRLKYLSICNTGIRTLPDVTKISSSEFNFILEICDNLHITTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAFNGTTLISLELKENIYLEKMHSGAFQGATGPSILDISSTKLQALPSHGLESIQTLIALSSYSLKTLPSKEKFTSLLVATLTYPSHCCAFRNLPKKEQNFSFSIFENFSKQCESTVRKADNETLYSAIFEENELSGWDYDYGFCSPKTLQCAPEPDAFNPCEDIMGYAFLRVLIWLINILAIFGNLTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCGAAGFFTVFASELSVYTLTVITLERWHTITYAVQLDQKLRLRHAIPIMLGGWLFSTLIATMPLVGISNYMKVSICLPMDVESTLSQVYILSILILNVVAFVVICACYIRIYFAVQNPELTAPNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKILLVLFYPVNSCANPFLYAIFTKAFQRDFLLLLSRFGCCKRRAELYRRKEFSAYTSNCKNGFPGASKPSQATLKLSTVHCQQPIPPRALTH
UniProtP16235
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2456
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL274609
Molecular formulaC63H76N10O9
IUPAC name1-[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2-[[(2R)-2-[[(2S)-3-(4-hydroxyphenyl)-2-[[(2S)-2-[(2-naphthalen-1-ylacetyl)amino]-3-phenylmethoxypropanoyl]amino]propanoyl]amino]-3-naphthalen-2-ylpropanoyl]amino]-4-methylpentanoyl]amino]pentanoyl]-N-ethylpyrrolidine-2-carboxamide
Molecular weight1117.36
Hydrogen bond acceptor10
Hydrogen bond donor9
XlogP6.7
SynonymsBDBM50405777
Inchi KeyTVAIWKOCVAYXMG-YFSJYYLMSA-N
Inchi IDInChI=1S/C63H76N10O9/c1-4-66-61(80)55-24-14-32-73(55)62(81)50(23-13-31-67-63(64)65)69-57(76)51(33-40(2)3)70-59(78)53(36-43-25-28-44-17-8-9-19-46(44)34-43)71-58(77)52(35-41-26-29-48(74)30-27-41)72-60(79)54(39-82-38-42-15-6-5-7-16-42)68-56(75)37-47-21-12-20-45-18-10-11-22-49(45)47/h5-12,15-22,25-30,34,40,50-55,74H,4,13-14,23-24,31-33,35-39H2,1-3H3,(H,66,80)(H,68,75)(H,69,76)(H,70,78)(H,71,77)(H,72,79)(H4,64,65,67)/t50-,51-,52-,53+,54-,55?/m0/s1
PubChem CID44314846
ChEMBLCHEMBL274609
IUPHARN/A
BindingDB50405777
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Kd3.63 nMPMID2552116BindingDB
Kd3.631 nMPMID2552116ChEMBL
Ki37.15 nMPMID2552116ChEMBL

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