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Name | B1 bradykinin receptor |
---|---|
Species | Macaca fascicularis (Crab-eating macaque) |
Gene | BDKRB1 |
Synonym | B1R BK-1 receptor |
Disease | N/A for non-human GPCRs |
Length | 352 |
Amino acid sequence | MASWPPLQLQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICSFGLLGNLFVLLVFLLPRRRLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGIIKANLFISIFLVVAISQDRYCVLVHPMASRRRQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQAVPDLNITACILLLPHEAWHFARIVELNILAFLLPLAAIIFFNYHILASLRGREEVSRTRCGGSKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFLAFTNSSLNPVIYVFAGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN |
UniProt | Q3BCU0 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL5155 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL491042 |
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Molecular formula | C28H26N6O2 |
IUPAC name | 1-benzyl-N-[2-[methyl-[[4-(1H-pyrazol-5-yl)phenyl]methyl]amino]-2-oxoethyl]benzimidazole-2-carboxamide |
Molecular weight | 478.556 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 2 |
XlogP | 3.6 |
Synonyms | BDBM50264678 N-(2-((4-(1H-pyrazol-5-yl)benzyl)(methyl)amino)-2-oxoethyl)-1-benzyl-1H-benzo[d]imidazole-2-carboxamide |
Inchi Key | TXTAZTVMAUOMRJ-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C28H26N6O2/c1-33(18-21-11-13-22(14-12-21)23-15-16-30-32-23)26(35)17-29-28(36)27-31-24-9-5-6-10-25(24)34(27)19-20-7-3-2-4-8-20/h2-16H,17-19H2,1H3,(H,29,36)(H,30,32) |
PubChem CID | 44580013 |
ChEMBL | CHEMBL491042 |
IUPHAR | N/A |
BindingDB | 50264678 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 2130.0 nM | PMID18752949 | BindingDB,ChEMBL |
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