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Name | Orexin receptor type 1 |
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Species | Rattus norvegicus (Rat) |
Gene | Hcrtr1 |
Synonym | hypocretin (orexin) receptor 1 hypocretin receptor 1 Hypocretin receptor type 1 Hctr1 orexin receptor type 1 [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 416 |
Amino acid sequence | MEPSATPGAQPGVPTSSGEPFHLPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFLIALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAVMVPQAAVMECSSVLPELANRTRLFSVCDERWADELYPKIYHSCFFFVTYLAPLGLMGMAYFQIFRKLWGPQIPGTTSALVRNWKRPSEQLEAQHQGLCTEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPSSSARHKSLSLQSRCSVSKVSEHVVLTTVTTVLS |
UniProt | P56718 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL1075232 |
IUPHAR | 321 |
DrugBank | N/A |
Name | Orexin receptor antagonist 22 |
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Molecular formula | C21H19FN6O2 |
IUPAC name | 2-[(3R,6R)-1-[2-fluoro-6-(triazol-2-yl)benzoyl]-6-methylpiperidin-3-yl]oxypyridine-4-carbonitrile |
Molecular weight | 406.421 |
Hydrogen bond acceptor | 7 |
Hydrogen bond donor | 0 |
XlogP | 3.1 |
Synonyms | SCHEMBL14876958 CHEMBL3642135 US20130102619, 22 BDBM97390 |
Inchi Key | TZVZAOSVMDBVLR-GDBMZVCRSA-N |
Inchi ID | InChI=1S/C21H19FN6O2/c1-14-5-6-16(30-19-11-15(12-23)7-8-24-19)13-27(14)21(29)20-17(22)3-2-4-18(20)28-25-9-10-26-28/h2-4,7-11,14,16H,5-6,13H2,1H3/t14-,16-/m1/s1 |
PubChem CID | 71526477 |
ChEMBL | CHEMBL3642135 |
IUPHAR | N/A |
BindingDB | 97390 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 5750.0 nM | , None | BindingDB,ChEMBL |
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