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Name | Gonadotropin-releasing hormone receptor |
---|---|
Species | Homo sapiens (Human) |
Gene | GNRHR |
Synonym | LHRHR GnRH I receptor Type I GnRHR gnRH receptor GnRH-R [ Show all ] |
Disease | Uterine leiomyoma Hypothalamic hypogonadism Ovulation Prostate cancer Prostate disease [ Show all ] |
Length | 328 |
Amino acid sequence | MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL |
UniProt | P30968 |
Protein Data Bank | N/A |
GPCR-HGmod model | P30968 |
3D structure model | This predicted structure model is from GPCR-EXP P30968. |
BioLiP | N/A |
Therapeutic Target Database | T12475 |
ChEMBL | CHEMBL1855 |
IUPHAR | 256 |
DrugBank | BE0000203 |
Name | Sufugolix |
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Molecular formula | C36H31F2N5O4S |
IUPAC name | 1-[4-[5-[[benzyl(methyl)amino]methyl]-1-[(2,6-difluorophenyl)methyl]-2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl]phenyl]-3-methoxyurea |
Molecular weight | 667.732 |
Hydrogen bond acceptor | 8 |
Hydrogen bond donor | 2 |
XlogP | 6.1 |
Synonyms | 388563-81-3 AKOS030629545 DTXSID40184893 ZINC3842924 1-[4-[1-[(2,6-difluorophenyl)methyl]-5-[(methyl-(phenylmethyl)amino)methyl]-2,4-dioxo-3-phenylthieno[4,5-e]pyrimidin-6-yl]phenyl]-3-methoxyurea [ Show all ] |
Inchi Key | UCQSBGOFELXYIN-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C36H31F2N5O4S/c1-41(20-23-10-5-3-6-11-23)21-28-31-33(44)43(26-12-7-4-8-13-26)36(46)42(22-27-29(37)14-9-15-30(27)38)34(31)48-32(28)24-16-18-25(19-17-24)39-35(45)40-47-2/h3-19H,20-22H2,1-2H3,(H2,39,40,45) |
PubChem CID | 3038517 |
ChEMBL | CHEMBL22055 |
IUPHAR | 1185 |
BindingDB | 50122654 |
DrugBank | DB06494 |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
N/A | N/A | DrugBank | |
IC50 | 0.06 nM | PMID21657270, PMID12502365 | BindingDB,ChEMBL |
IC50 | 0.1 nM | PMID18419112, PMID21657270, PMID12502365 | BindingDB,ChEMBL |
IC50 | 0.3 nM | PMID16420049 | BindingDB,ChEMBL |
IC50 | 0.4 nM | PMID16420049 | BindingDB,ChEMBL |
IC50 | 0.5 nM | PMID17034124, PMID16420049 | BindingDB,ChEMBL |
IC50 | 0.6 nM | PMID12502365, PMID16420049 | BindingDB,ChEMBL |
IC50 | 0.7 nM | PMID17034124, PMID16420049 | BindingDB,ChEMBL |
IC50 | 0.8 nM | PMID17034124, PMID16420049 | BindingDB,ChEMBL |
IC50 | 0.9 nM | PMID16420049 | BindingDB,ChEMBL |
IC50 | 1.1 nM | PMID16420049 | BindingDB,ChEMBL |
IC50 | 1.2 nM | PMID17034124, PMID16420049 | BindingDB,ChEMBL |
IC50 | 1.3 nM | PMID16420049 | BindingDB,ChEMBL |
IC50 | 1.4 nM | PMID16420049 | BindingDB,ChEMBL |
IC50 | 1.6 nM | PMID21657270 | BindingDB,ChEMBL |
IC50 | 1.8 nM | PMID16420049 | BindingDB,ChEMBL |
IC50 | 1.9 nM | PMID17034124, PMID21657270, PMID16420049 | BindingDB,ChEMBL |
IC50 | 2.0 nM | PMID16420049 | BindingDB,ChEMBL |
IC50 | 2.3 nM | PMID16420049 | BindingDB,ChEMBL |
IC50 | 2.5 nM | PMID16420049 | BindingDB,ChEMBL |
IC50 | 3.0 nM | PMID16420049 | BindingDB,ChEMBL |
IC50 | 4.3 nM | PMID16420049 | BindingDB,ChEMBL |
IC50 | 5.2 nM | PMID16420049 | BindingDB,ChEMBL |
IC50 | 6.0 nM | PMID17034124 | BindingDB,ChEMBL |
IC50 | 6.3 nM | PMID16420049 | BindingDB,ChEMBL |
IC50 | 8.5 nM | PMID16420049 | BindingDB,ChEMBL |
IC50 | 9.7 nM | PMID16420049 | BindingDB,ChEMBL |
IC50 | 10.0 nM | PMID17034124, PMID12502365, PMID16420049 | BindingDB,ChEMBL |
IC50 | 12.0 nM | PMID17034124 | BindingDB,ChEMBL |
IC50 | 12.1 nM | PMID16420049 | BindingDB,ChEMBL |
IC50 | 23.4 nM | PMID16420049 | BindingDB,ChEMBL |
IC50 | 24.0 nM | PMID17034124 | BindingDB,ChEMBL |
IC50 | 24.4 nM | PMID16420049 | BindingDB,ChEMBL |
IC50 | 94.9 nM | PMID16420049 | BindingDB,ChEMBL |
IC50 | 100.0 nM | PMID17034124 | BindingDB,ChEMBL |
IC50 | 108.0 nM | PMID16420049 | BindingDB,ChEMBL |
IC50 | 110.0 nM | PMID17034124 | BindingDB,ChEMBL |
IC50 | 115.0 nM | PMID16420049 | BindingDB,ChEMBL |
IC50 | 120.0 nM | PMID17034124 | BindingDB,ChEMBL |
IC50 | 148.0 nM | PMID16420049 | BindingDB,ChEMBL |
IC50 | 190.0 nM | PMID17034124 | BindingDB,ChEMBL |
IC50 | 192.0 nM | PMID16420049 | BindingDB,ChEMBL |
IC50 | 193.0 nM | PMID16420049 | BindingDB,ChEMBL |
IC50 | 240.0 nM | PMID16420049 | BindingDB,ChEMBL |
IC50 | 242.0 nM | PMID16420049 | BindingDB,ChEMBL |
IC50 | 270.0 nM | PMID21657270 | BindingDB,ChEMBL |
IC50 | 470.0 nM | PMID16420049 | BindingDB,ChEMBL |
IC50 | 1070.0 nM | PMID16420049 | BindingDB,ChEMBL |
Ki | 0.1 nM | PMID12502365 | IUPHAR |
Ki | 0.2 nM | PMID14505682 | ChEMBL |
Ki | 0.2 nM | PMID14505682 | BindingDB |
Ratio IC50 | 0.6 - | PMID17034124 | ChEMBL |
Ratio IC50 | 0.9 - | PMID17034124 | ChEMBL |
Ratio IC50 | 1.5 - | PMID17034124 | ChEMBL |
Ratio IC50 | 2.4 - | PMID17034124 | ChEMBL |
Ratio IC50 | 7.5 - | PMID17034124 | ChEMBL |
Ratio IC50 | 12.0 - | PMID17034124 | ChEMBL |
Ratio IC50 | 15.0 - | PMID17034124 | ChEMBL |
Ratio IC50 | 16.0 - | PMID21657270 | ChEMBL |
Ratio IC50 | 30.0 - | PMID17034124 | ChEMBL |
Ratio IC50 | 32.0 - | PMID21657270 | ChEMBL |
Ratio IC50 | 125.0 - | PMID17034124 | ChEMBL |
Ratio IC50 | 138.0 - | PMID17034124 | ChEMBL |
Ratio IC50 | 150.0 - | PMID17034124 | ChEMBL |
Ratio IC50 | 238.0 - | PMID17034124 | ChEMBL |
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