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Name | Gonadotropin-releasing hormone receptor |
---|---|
Species | Macaca mulatta (Rhesus macaque) |
Gene | GNRHR |
Synonym | GnRH receptor GnRH-R |
Disease | N/A for non-human GPCRs |
Length | 59 |
Amino acid sequence | VAFATSFTVCWTPYYVLGIWYWFDPEMLNRVSDPVNHFFFLFAFLNPCFDPLIYGYFSL |
UniProt | Q8SPZ1 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL5647 |
IUPHAR | N/A |
DrugBank | N/A |
Name | Sufugolix |
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Molecular formula | C36H31F2N5O4S |
IUPAC name | 1-[4-[5-[[benzyl(methyl)amino]methyl]-1-[(2,6-difluorophenyl)methyl]-2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl]phenyl]-3-methoxyurea |
Molecular weight | 667.732 |
Hydrogen bond acceptor | 8 |
Hydrogen bond donor | 2 |
XlogP | 6.1 |
Synonyms | BDBM50122654 HY-100209 Sufugolix(TAK-013) 1-[4-(5-{[BENZYL(METHYL)AMINO]METHYL}-1-[(2,6-DIFLUOROPHENYL)METHYL]-2,4-DIOXO-3-PHENYL-1H,2H,3H,4H-THIENO[2,3-D]PYRIMIDIN-6-YL)PHENYL]-3-METHOXYUREA 5-(n-benzyl-n-methylaminomethyl)-1-(2,6-difluorobenzyl)-6-[4-(3-methoxyureido)phenyl]-3-phenylthieno[2,3-d]pyrimidine-2,4(1h, 3h)-dione [ Show all ] |
Inchi Key | UCQSBGOFELXYIN-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C36H31F2N5O4S/c1-41(20-23-10-5-3-6-11-23)21-28-31-33(44)43(26-12-7-4-8-13-26)36(46)42(22-27-29(37)14-9-15-30(27)38)34(31)48-32(28)24-16-18-25(19-17-24)39-35(45)40-47-2/h3-19H,20-22H2,1-2H3,(H2,39,40,45) |
PubChem CID | 3038517 |
ChEMBL | CHEMBL22055 |
IUPHAR | 1185 |
BindingDB | 50122654 |
DrugBank | DB06494 |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 0.6 nM | PMID18419112 | BindingDB,ChEMBL |
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