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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Neuropeptide Y receptor type 2
Species	Homo sapiens (Human)
Gene	NPY2R
Synonym	NPY2-R NPY-Y2 receptor neuropeptide Y receptor type 2 Y2 receptor
Disease	Diabetes Metabolic disorders Obesity
Length	381
Amino acid sequence	MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV
UniProt	P49146
Protein Data Bank	N/A
GPCR-HGmod model	P49146
3D structure model	This predicted structure model is from GPCR-EXP P49146.
BioLiP	N/A
Therapeutic Target Database	T10670
ChEMBL	CHEMBL4018
IUPHAR	306
DrugBank	BE0002419

Ligand

Name	3-Methyl-5-nitro-1H-indole-2-carboxylic acid
Molecular formula	C10H8N2O4
IUPAC name	3-methyl-5-nitro-1H-indole-2-carboxylic acid
Molecular weight	220.184
Hydrogen bond acceptor	4
Hydrogen bond donor	2
XlogP	2.1
Synonyms	CHEMBL1373205 SMR000277900 446830-73-5 HMS2658N12 ST50277055 1H-Indole-2-carboxylic acid, 3-methyl-5-nitro- AKOS000300634 BUWLROXHVDVDKY-UHFFFAOYSA-N Oprea1_006521 3-methyl-5-nitroindole-2-carboxylic acid cid_1078087 SR-01000324661 MCULE-2782718818 TR-055602 3-methyl-5-nitro-1 h-indole-2-carboxylic acid BAS 05150787 SCHEMBL6847834 3815AE CTK5I3552 SR-01000324661-1 AC1LL3DD BDBM61818 MLS000716383 ZINC790611 [ Show all ]
Inchi Key	BUWLROXHVDVDKY-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H8N2O4/c1-5-7-4-6(12(15)16)2-3-8(7)11-9(5)10(13)14/h2-4,11H,1H3,(H,13,14)
PubChem CID	1078087
ChEMBL	CHEMBL1373205
IUPHAR	N/A
BindingDB	61818
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	6991.0 nM	, PubChem BioAssay data set	BindingDB,ChEMBL

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