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GPCR

Name	5-hydroxytryptamine receptor 7
Species	Cavia porcellus (Guinea pig)
Gene	HTR7
Synonym	5-HT-7 5-HT-X 5-HT7 Serotonin receptor 7
Disease	N/A for non-human GPCRs
Length	446
Amino acid sequence	MMGVNSSGRPDLYGHLHSILLPGRGLPDWSPDGGADPGVSTWTPRLLSGVPEVAASPSPSWDGTWDNVSGCGEQINYGRAEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVIPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMPKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYRIYKAARKSAAKHKFPGFPRVQPESIISLNGMVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTACSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPECVLQNSDYCRKKGHDS
UniProt	P50407
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5494
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	mianserin
Molecular formula	C18H20N2
IUPAC name	5-methyl-2,5-diazatetracyclo[13.4.0.02,7.08,13]nonadeca-1(19),8,10,12,15,17-hexaene
Molecular weight	264.372
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	3.4
Synonyms	FT-0697022 KBio2_004869 LS-61197 Mianserine NCGC00015656-06 5-methyl-2,5-diazatetracyclo[13.4.0.0;{2,7}.0;{8,13}]nonadeca-1(15),8(13),9,11,16,18-hexaene Norval AN-15691 Prestwick3_000099 BRD-A19661776-003-05-2 Spectrum5_001772 CHEBI:51137 X5019 Dibenzo(c,f)pyrazino(1,2-a)azepine, 1,2,3,4,10,14b-hexahydro-2-methyl- DSSTox_CID_3317 HSDB 7182 KBioGR_001820 mianserin a Mianserinum [INN-Latin] NCGC00015656-10 78684-63-6 PDSP1_001532 Biomol-NT_000135 SPBio_000986 BSPBio_000058 Tolvin (TN) CS-2078 DTXSID6023317 KBio1_000844 Lerivon Mianserina NCGC00015656-04 21535-47-7 (mono-hydrochloride) NCGC00024926-04 AKOS005216268 Prestwick1_000099 BPBio1_000331 Spectrum3_001836 CAS-24219-97-4 Tox21_110191_1 GTPL135 KBio2_007437 Mianserine [INN-French] 1,2,3,4,10,14b-Hexahydro-2-methyldibenzo(c,f)pyrazino(1,2-a)azepine NCGC00015656-08 5-methyl-2,5-diazatetracyclo[13.4.0.0^{2,7}.0^{8,13}]nonadeca-1(15),8(13),9,11,16,18-hexaene Norval (TN) API0000656 SBI-0050722.P003 BRD-A19661776-003-16-9 Spectrum_001810 Dibenzo[c,f]pyrazino[1,2-a]azepine, 1,2,3,4,10,14b-hexahydro-2-methyl- DSSTox_GSID_23317 HY-B0188 KBioSS_002303 Mianserin Monohydrochloride Mianseryna 2-Methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine NCGC00015656-12 AC-631 PDSP2_001516 Bolvidon (TN) SPBio_001997 BSPBio_003511 Tolvon (TN) D08216 EINECS 246-088-6 KBio2_002301 Lopac0_000744 Mianserina [INN-Spanish] (+-)-Athymil NCGC00015656-05 24219-97-4 NINDS_000844 AM20041174 Prestwick2_000099 BRD-A19661776-001-01-5 Spectrum4_001260 CCG-204829 UEQUQVLFIPOEMF-UHFFFAOYSA-N DB06148 DivK1c_000844 HMS2089A04 KBio3_003016 Mianserin (INN) Mianserinum 1,2,3,4,10,14b-hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepine NCGC00015656-09 5-methyl-2,5-diazatetracyclo[13.4.0.0^{2,7}.0^{8,13}]nonadeca-1(19),8,10,12,15,17-hexaene Oprea1_703627 BDBM50222218 SCHEMBL18020 BRN 0755346 Tolvan CHEMBL6437 DSSTox_RID_76974 IDI1_000844 L000736 Mianserin [INN:BAN] Mianseryna [Polish] 2-Methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine # NCGC00024926-03 AC1L1HLP Prestwick0_000099 BPBio1_000064 Spectrum2_001203 C18H20N2 Tox21_110191 D0R6RO [ Show all ]
Inchi Key	UEQUQVLFIPOEMF-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H20N2/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19/h2-9,18H,10-13H2,1H3
PubChem CID	4184
ChEMBL	CHEMBL6437
IUPHAR	135
BindingDB	N/A
DrugBank	DB06148
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	107.15 nM	PMID7647964	PDSP
Ki	660.69 nM	PMID7647964	PDSP

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