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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Nociceptin receptor
Species	Rattus norvegicus (Rat)
Gene	Oprl1
Synonym	NOP receptor NOP-r NOPr OP4 Orphanin FQ receptor ROR-C NOCIR nociceptin/orphanin FQ receptor nociceptin receptor ORL1 N/OFQ receptor MOR-C KOR-3 kappa3-related opioid receptor Kappa-type 3 opioid receptor XOR1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	367
Amino acid sequence	MESLFPAPYWEVLYGSHFQGNLSLLNETVPHHLLLNASHSAFLPLGLKVTIVGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPAPQDYWGPVFAICIFLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASSLHREMQVSDRVRSIAKDVGLGCKTSETVPRPA
UniProt	P35370
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4503
IUPHAR	320
DrugBank	N/A

Ligand

Name	CHEMBL427007
Molecular formula	C25H23BrN2O3
IUPAC name	8-[[(2S,4S,6S)-17-bromo-3,13-dioxatetracyclo[12.4.0.02,6.07,12]octadeca-1(14),7,9,11,15,17-hexaen-4-yl]methyl]-N,N-dimethyl-7-oxa-8-azabicyclo[4.2.0]octa-1(6),2,4-trien-3-amine
Molecular weight	479.374
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	5.3
Synonyms	BDBM50167761 [8-((2S,3aS,12bS)-11-Bromo-2,3,3a,12b-tetrahydro-1,8-dioxa-dibenzo[e,h]azulen-2-ylmethyl)-7-oxa-8-aza-bicyclo[4.2.0]octa-1(6),2,4-trien-3-yl]-dimethyl-amine
Inchi Key	UFVZMDZVXDJFLY-KMEZTADASA-N
Inchi ID	InChI=1S/C25H23BrN2O3/c1-27(2)16-8-10-24-21(12-16)28(31-24)14-17-13-19-18-5-3-4-6-22(18)30-23-9-7-15(26)11-20(23)25(19)29-17/h3-12,17,19,25H,13-14H2,1-2H3/t17-,19-,25-/m0/s1
PubChem CID	44402566
ChEMBL	CHEMBL427007
IUPHAR	N/A
BindingDB	50167761
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
Ki	2254.0 nM	PMID15911276	BindingDB,ChEMBL

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