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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Gonadotropin-releasing hormone receptor
Species	Rattus norvegicus (Rat)
Gene	Gnrhr
Synonym	luteinizing hormone-releasing hormone (LHRH) receptor luliberin receptor LHRHR LHRH receptor GNRHR1 GnRHR GnRH1 receptor GnRH-R GnRH receptor GnRH I receptor Type I GnRHR [ Show all ]
Disease	N/A for non-human GPCRs
Length	327
Amino acid sequence	MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
UniProt	P30969
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3066
IUPHAR	256
DrugBank	N/A

Ligand

Name	CHEMBL407073
Molecular formula	C64H80FN13O10
IUPAC name	(2S)-N-[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2R)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-1-[(2S)-2-[3-(4-fluorophenyl)propanoylamino]-3-(1H-indol-3-yl)propanoyl]-4-hydroxypyrrolidine-2-carboxamide
Molecular weight	1210.42
Hydrogen bond acceptor	12
Hydrogen bond donor	12
XlogP	4.5
Synonyms	N/A
Inchi Key	BVMFWZALHZIKAK-GHGRYVAGSA-N
Inchi ID	InChI=1S/C64H80FN13O10/c1-4-68-60(85)54-16-10-28-77(54)62(87)49(15-9-27-69-64(66)67)73-57(82)50(29-37(2)3)74-59(84)52(31-40-34-70-47-13-7-5-11-45(40)47)75-58(83)51(30-39-19-24-43(79)25-20-39)76-61(86)55-33-44(80)36-78(55)63(88)53(32-41-35-71-48-14-8-6-12-46(41)48)72-56(81)26-21-38-17-22-42(65)23-18-38/h5-8,11-14,17-20,22-25,34-35,37,44,49-55,70-71,79-80H,4,9-10,15-16,21,26-33,36H2,1-3H3,(H,68,85)(H,72,81)(H,73,82)(H,74,84)(H,75,83)(H,76,86)(H4,66,67,69)/t44?,49-,50-,51-,52+,53-,54+,55-/m0/s1
PubChem CID	44375128
ChEMBL	CHEMBL407073
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Ki	7.76247e+17 nM	PMID7510341	ChEMBL

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