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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Growth hormone secretagogue receptor type 1
Species	Rattus norvegicus (Rat)
Gene	Ghsr
Synonym	GH-releasing peptide receptor Ghrelin receptor ghrelin receptor 1a GHRP GHS-R growth hormone-releasing peptide receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	364
Amino acid sequence	MWNATPSEEPEPNVTLDLDWDASPGNDSLPDELLPLFPAPLLAGVTATCVALFVVGISGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVILVIWAVAFCSAGPIFVLVGVEHENGTDPRDTNECRATEFAVRSGLLTVMVWVSSVFFFLPVFCLTVLYSLIGRKLWRRRGDAAVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFKLLGFESFSQRKLSTLKDESSRAWTKSSINT
UniProt	O08725
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3278
IUPHAR	246
DrugBank	N/A

Ligand

Name	CHEMBL274340
Molecular formula	C28H34N4O3
IUPAC name	2-amino-N-[(2R)-3-(1H-indol-3-yl)-1-oxo-1-spiro[3,4-dihydrochromene-2,3'-piperidine]-1'-ylpropan-2-yl]-2-methylpropanamide
Molecular weight	474.605
Hydrogen bond acceptor	4
Hydrogen bond donor	3
XlogP	3.3
Synonyms	BDBM50073034 1N-[1-(1H-3-indolylmethyl)-2-oxo-2-spiro[3,4-dihydro-2H-chromene-2,3''-(hexahydropyridine)]-1-yl-(1R)-ethyl]-2-amino-2-methylpropanamide
Inchi Key	UMYPPGBOOAJIKE-YFIOFSHDSA-N
Inchi ID	InChI=1S/C28H34N4O3/c1-27(2,29)26(34)31-23(16-20-17-30-22-10-5-4-9-21(20)22)25(33)32-15-7-13-28(18-32)14-12-19-8-3-6-11-24(19)35-28/h3-6,8-11,17,23,30H,7,12-16,18,29H2,1-2H3,(H,31,34)/t23-,28?/m1/s1
PubChem CID	44269019
ChEMBL	CHEMBL274340
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	2.9 nM	PMID9925440	ChEMBL

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