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Name | D(1A) dopamine receptor |
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Species | Rattus norvegicus (Rat) |
Gene | Drd1 |
Synonym | D1 receptor D1A DADR dopamine D1 receptor Dopamine-1A receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 446 |
Amino acid sequence | MAPNTSTMDEAGLPAERDFSFRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPLGPFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFQYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTWPLDGNFTSLEDTEDDNCDTRLSRTYAISSSLISFYIPVAIMIVTYTSIYRIAQKQIRRISALERAAVHAKNCQTTAGNGNPVECAQSESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFISNCMVPFCGSEETQPFCIDSITFDVFVWFGWANSSLNPIIYAFNADFQKAFSTLLGCYRLCPTTNNAIETVSINNNGAVVFSSHHEPRGSISKDCNLVYLIPHAVGSSEDLKKEEAGGIAKPLEKLSPALSVILDYDTDVSLEKIQPVTHSGQHST |
UniProt | P18901 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL265 |
IUPHAR | 214 |
DrugBank | N/A |
Name | CHEMBL135616 |
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Molecular formula | C22H29BrN2O |
IUPAC name | 8-bromo-3-[4-(dimethylamino)butyl]-5-phenyl-1,2,4,5-tetrahydro-3-benzazepin-7-ol |
Molecular weight | 417.391 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 1 |
XlogP | 4.8 |
Synonyms | 8-Bromo-3-(4-dimethylamino-butyl)-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol BDBM50029347 |
Inchi Key | AEFMBWDXTMRYHD-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C22H29BrN2O/c1-24(2)11-6-7-12-25-13-10-18-14-21(23)22(26)15-19(18)20(16-25)17-8-4-3-5-9-17/h3-5,8-9,14-15,20,26H,6-7,10-13,16H2,1-2H3 |
PubChem CID | 10740666 |
ChEMBL | CHEMBL135616 |
IUPHAR | N/A |
BindingDB | 50029347 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 1490.0 nM | PMID7473556 | BindingDB,ChEMBL |
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