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GPCR

NameD(2) dopamine receptor
SpeciesChlorocebus aethiops (Green monkey)
GeneDRD2
SynonymDopamine D2 receptor
DiseaseN/A for non-human GPCRs
Length443
Amino acid sequenceMDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSKIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRSHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKNHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
UniProtP52702
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5456
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL28321
Molecular formulaC22H25N3O
IUPAC name1-(2-methoxyphenyl)-4-[(1-phenylpyrrol-3-yl)methyl]piperazine
Molecular weight347.462
Hydrogen bond acceptor3
Hydrogen bond donor0
XlogP3.7
Synonyms1-(2-Methoxy-phenyl)-4-(1-phenyl-1H-pyrrol-3-ylmethyl)-piperazine
BDBM50048233
1-Phenyl-3-[[4-(2-methoxyphenyl)-1-piperazinyl]methyl]-1H-pyrrole
Inchi KeyUPXJKNQVKALXKP-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H25N3O/c1-26-22-10-6-5-9-21(22)24-15-13-23(14-16-24)17-19-11-12-25(18-19)20-7-3-2-4-8-20/h2-12,18H,13-17H2,1H3
PubChem CID10450375
ChEMBLCHEMBL28321
IUPHARN/A
BindingDB50048233
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki0.7 nMPMID8523409ChEMBL
Ki0.7 nMPMID8523409BindingDB

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