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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Trace amine-associated receptor 1
Species	Rattus norvegicus (Rat)
Gene	Taar1
Synonym	TA1 receptor TaR-1 TAR1 Trace amine receptor 1 TRAR1
Disease	N/A for non-human GPCRs
Length	332
Amino acid sequence	MHLCHNSANISHTNSNWSRDVRASLYSLISLIILTTLVGNLIVIISISHFKQLHTPTNWLLHSMAVVDFLLGCLVMPYSMVRTVEHCWYFGELFCKLHTSTDIMLSSASILHLAFISIDRYYAVCDPLRYKAKINLAAIFVMILISWSLPAVFAFGMIFLELNLEGVEELYHNQVFCLRGCFPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRANLQVGLEGESRAPQSKETKAAKTLGIMVGVFLLCWCPFFFCMVLDPFLGYVIPPTLNDTLNWFGYLNSAFNPMVYAFFYPWFRRALKMVLFGKIFQKDSSRSKLFL
UniProt	Q923Y9
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3833
IUPHAR	364
DrugBank	N/A

Ligand

Name	CHEMBL229636
Molecular formula	C21H22NO+
IUPAC name	[2-(4-phenoxyphenyl)-3-phenylpropyl]azanium
Molecular weight	304.413
Hydrogen bond acceptor	1
Hydrogen bond donor	1
XlogP	4.5
Synonyms	BDBM50212676 2-(4-phenoxyphenyl)-3-phenylpropan-1-amine hydrochloride
Inchi Key	BWAPUZYRWOPZPW-UHFFFAOYSA-O
Inchi ID	InChI=1S/C21H21NO/c22-16-19(15-17-7-3-1-4-8-17)18-11-13-21(14-12-18)23-20-9-5-2-6-10-20/h1-14,19H,15-16,22H2/p+1
PubChem CID	91935921
ChEMBL	N/A
IUPHAR	N/A
BindingDB	50212676
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	140.0 nM	PMID17497842	BindingDB

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