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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Lutropin-choriogonadotropic hormone receptor
Species	Rattus norvegicus (Rat)
Gene	Lhcgr
Synonym	Luteinizing hormone receptor LSH-R LHR LH/CG-R LH-R LH receptor LGR2 LCGR Choriogonadotropin receptor lutropin-choriogonadotropic hormone receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	700
Amino acid sequence	MGRRVPALRQLLVLAVLLLKPSQLQSRELSGSRCPEPCDCAPDGALRCPGPRAGLARLSLTYLPVKVIPSQAFRGLNEVVKIEISQSDSLERIEANAFDNLLNLSELLIQNTKNLLYIEPGAFTNLPRLKYLSICNTGIRTLPDVTKISSSEFNFILEICDNLHITTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAFNGTTLISLELKENIYLEKMHSGAFQGATGPSILDISSTKLQALPSHGLESIQTLIALSSYSLKTLPSKEKFTSLLVATLTYPSHCCAFRNLPKKEQNFSFSIFENFSKQCESTVRKADNETLYSAIFEENELSGWDYDYGFCSPKTLQCAPEPDAFNPCEDIMGYAFLRVLIWLINILAIFGNLTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCGAAGFFTVFASELSVYTLTVITLERWHTITYAVQLDQKLRLRHAIPIMLGGWLFSTLIATMPLVGISNYMKVSICLPMDVESTLSQVYILSILILNVVAFVVICACYIRIYFAVQNPELTAPNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKILLVLFYPVNSCANPFLYAIFTKAFQRDFLLLLSRFGCCKRRAELYRRKEFSAYTSNCKNGFPGASKPSQATLKLSTVHCQQPIPPRALTH
UniProt	P16235
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2456
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL2369791
Molecular formula	C46H67N11O9
IUPAC name	N-[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]-1H-indole-3-carboxamide
Molecular weight	918.11
Hydrogen bond acceptor	10
Hydrogen bond donor	11
XlogP	2.1
Synonyms	BDBM50405765
Inchi Key	USFGGIRCAFZEHP-ZUQDGUHMSA-N
Inchi ID	InChI=1S/C46H67N11O9/c1-6-49-44(65)38-14-10-20-57(38)45(66)33(13-9-19-50-46(47)48)52-40(61)34(21-26(2)3)53-41(62)35(22-27(4)5)54-42(63)36(23-28-15-17-29(59)18-16-28)55-43(64)37(25-58)56-39(60)31-24-51-32-12-8-7-11-30(31)32/h7-8,11-12,15-18,24,26-27,33-38,51,58-59H,6,9-10,13-14,19-23,25H2,1-5H3,(H,49,65)(H,52,61)(H,53,62)(H,54,63)(H,55,64)(H,56,60)(H4,47,48,50)/t33-,34-,35+,36-,37-,38-/m0/s1
PubChem CID	14557592
ChEMBL	CHEMBL2369791
IUPHAR	N/A
BindingDB	50405765
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Kd	190.55 nM	PMID2552116	BindingDB,ChEMBL
Ki	204.17 nM	PMID2552116	ChEMBL

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