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GPCR

Name5-hydroxytryptamine receptor 4
SpeciesSus scrofa (Pig)
GeneHTR4
Synonym5-HT-4
5-HT4
Serotonin receptor 4
DiseaseN/A for non-human GPCRs
Length137
Amino acid sequenceCCQPLVYRNKMTPLRVAVLLAGCWAIPVLISFLPIMQGWNNIGITDLIEKRKFHQNSNSTYCIFMVNKPYAITCSVVAFYIPFLLMVLAYWRIYVTAKEHAHQIQMLQRAGAPAEGRPPSADQHSTHRMRTETKAAK
UniProtQ29006
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLN/A
IUPHARN/A
DrugBankN/A

Ligand

NameSB 204741
Molecular formulaC14H14N4OS
IUPAC name1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea
Molecular weight286.353
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP2.4
SynonymsNCGC00015923-03
NSC_3277600
SB-204741
Tox21_500255
1-(1-methyl-1H-indol-5-yl)-3-(3-methylisothiazol-5-yl)urea
[ Show all ]
Inchi KeyUSFUFHFQWXDVMH-UHFFFAOYSA-N
Inchi IDInChI=1S/C14H14N4OS/c1-9-7-13(20-17-9)16-14(19)15-11-3-4-12-10(8-11)5-6-18(12)2/h3-8H,1-2H3,(H2,15,16,19)
PubChem CID3277600
ChEMBLCHEMBL323356
IUPHAR221
BindingDB84991
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki<10000.0 nMPMID8788493PDSP,BindingDB

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