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GPCR

NameFree fatty acid receptor 1
SpeciesHomo sapiens (Human)
GeneFFAR1
SynonymFFA1R
G protein-coupled receptor 40
G-protein coupled receptor 40
GPR40
FFA1 receptor
DiseaseType 2 diabetes
Non-insulin dependent diabetes
Diabetes
Length300
Amino acid sequenceMDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
UniProtO14842
Protein Data Bank5tzy, 5tzr
GPCR-HGmod modelO14842
3D structure modelThis structure is from PDB ID 5tzy.
BioLiPBL0380462, BL0380463, BL0380464
Therapeutic Target DatabaseT25608
ChEMBLCHEMBL4422
IUPHAR225
DrugBankBE0000688

Ligand

NameCHEMBL229116
Molecular formulaC21H26O3
IUPAC name3-(4-hexoxyphenyl)-3-phenylpropanoic acid
Molecular weight326.436
Hydrogen bond acceptor3
Hydrogen bond donor1
XlogP5.4
Synonyms3-Aryl-3-(4-phenoxy)-propionic Acid derivative, 9
3-[4-(hexyloxy)phenyl]-3-phenylpropanoic acid
BDBM22480
SCHEMBL2949131
Inchi KeyUWMJXIBMHISJML-UHFFFAOYSA-N
Inchi IDInChI=1S/C21H26O3/c1-2-3-4-8-15-24-19-13-11-18(12-14-19)20(16-21(22)23)17-9-6-5-7-10-17/h5-7,9-14,20H,2-4,8,15-16H2,1H3,(H,22,23)
PubChem CID16738221
ChEMBLCHEMBL229116
IUPHARN/A
BindingDB22480
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Activity68.0 %PMID17500511ChEMBL
EC502880.0 nMPMID17500511BindingDB
ED502.88 uMPMID17500511ChEMBL

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