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GPCR

Name5-hydroxytryptamine receptor 1A
SpeciesRattus norvegicus (Rat)
GeneHtr1a
Synonym5-HT1A receptor
5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
5-HT1A
ADRB2RL1
ADRBRL1
[ Show all ]
DiseaseN/A for non-human GPCRs
Length422
Amino acid sequenceMDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
UniProtP19327
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL273
IUPHAR1
DrugBankN/A

Ligand

NameCHEMBL134843
Molecular formulaC17H25NO6
IUPAC name2-[(3-methylbutylamino)methyl]-3,4-dihydro-2H-chromen-7-ol;oxalic acid
Molecular weight339.388
Hydrogen bond acceptor7
Hydrogen bond donor4
XlogPNone
SynonymsSCHEMBL7311582
Inchi KeyAEIFXZHCJWNECR-UHFFFAOYSA-N
Inchi IDInChI=1S/C15H23NO2.C2H2O4/c1-11(2)7-8-16-10-14-6-4-12-3-5-13(17)9-15(12)18-14;3-1(4)2(5)6/h3,5,9,11,14,16-17H,4,6-8,10H2,1-2H3;(H,3,4)(H,5,6)
PubChem CID21479400
ChEMBLCHEMBL134843
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessPartition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
Ki67.0 nMPMID9435894ChEMBL

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