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Name | Mu-type opioid receptor |
---|---|
Species | Rattus norvegicus (Rat) |
Gene | Oprm1 |
Synonym | Opioid receptor B opioid receptor OP3 mu receptor MOR-1 [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 398 |
Amino acid sequence | MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP |
UniProt | P33535 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL270 |
IUPHAR | 319 |
DrugBank | N/A |
Name | naloxone |
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Molecular formula | C19H21NO4 |
IUPAC name | (4R,4aS,7aR,12bS)-4a,9-dihydroxy-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one |
Molecular weight | 327.38 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 2 |
XlogP | 2.1 |
Synonyms | Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, (5alpha)- (9CI) 1-N-Allyl-7,8-dihydro-14-hydroxynormorphinone N-Allyl-noroxymorphone 3,14-dihydroxy-17-(prop-2-en-1-yl)-4,5alpha-epoxymorphinan-6-one 4-allyl-10,17-dihydroxy-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one(naloxone)C2H2O4 [ Show all ] |
Inchi Key | UZHSEJADLWPNLE-GRGSLBFTSA-N |
Inchi ID | InChI=1S/C19H21NO4/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11/h2-4,14,17,21,23H,1,5-10H2/t14-,17+,18+,19-/m1/s1 |
PubChem CID | 5284596 |
ChEMBL | CHEMBL80 |
IUPHAR | 1638, 1676 |
BindingDB | 50000788, 54795 |
DrugBank | DB01183 |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Control | 105.0 % | PMID2167979 | ChEMBL |
Control | 111.0 % | PMID2167979 | ChEMBL |
Kd | 0.4 nM | PMID3007760 | BindingDB |
Kd | 0.4 nM | PMID3007760 | ChEMBL |
Kd | 3.0 nM | PMID10782696 | BindingDB,ChEMBL |
Kd | 5.0 nM | PMID3007760 | BindingDB,ChEMBL |
Ki | 0.559 nM | PMID7562497 | BindingDB |
Ki | 0.9 nM | PMID10585536 | BindingDB |
Ki | 1.07 nM | PMID2563773 | BindingDB,ChEMBL |
Ki | 1.4 nM | PMID10741545 | BindingDB,ChEMBL |
Ki | 2.0 nM | PMID25087049 | BindingDB |
Ki | 2.0 nM | PMID25087049 | ChEMBL |
Ki | 3.7 nM | PMID8410998, PMID8057274 | BindingDB,ChEMBL |
Ki | 6.3 nM | PMID8410999 | BindingDB,ChEMBL |
Ki | 3550.0 nM | PMID7562497 | BindingDB |
Kp | 20.7 - | PMID2831361 | ChEMBL |
Kp | 980000000.0 - | PMID2999404 | ChEMBL |
KT | 19.4 - | PMID2831361 | ChEMBL |
Kt | 260000000.0 - | PMID2999404 | ChEMBL |
ln Kp | 20.7 - | PMID2999404 | ChEMBL |
ln Kt | 19.4 - | PMID2999404 | ChEMBL |
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