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GPCR

Name	Muscarinic acetylcholine receptor M1
Species	Homo sapiens (Human)
Gene	CHRM1
Synonym	cholinergic receptor cholinergic receptor, muscarinic 1 cholinergic receptor, muscarinic 1, CNS Chrm-1 M1 receptor M1R M1 muscarinic acetylcholine receptor [ Show all ]
Disease	Functional bowel syndrome; Irritable bowel syndrome Glaucoma Peptic ulcer Parkinsonism; Extrapyramidal disorders secondary to neuroleptic drug therapy Visceral spasms Parkinson's disease; Dystonia Parkinson's disease Neurological disease Neuropathic pain Overactive bladder disorder Excessive sweating; Stomach ulcer Cognitive disorders Chronic obstructive pulmonary disease Schizophrenia Schizophrenia; Dementia Schizophrenia; Schizoaffective disorders Unspecified Urinary incontinence Anesthesia Alzheimer disease Abdominal stomach pain; Irritable bowel syndrome [ Show all ]
Length	460
Amino acid sequence	MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
UniProt	P11229
Protein Data Bank	5cxv
GPCR-HGmod model	P11229
3D structure model	This structure is from PDB ID 5cxv.
BioLiP	BL0339262, BL0339261, BL0339263
Therapeutic Target Database	T28893
ChEMBL	CHEMBL216
IUPHAR	13
DrugBank	BE0000092

Ligand

Name	N1-(3-(1,3-Dioxoisoindolin-2-yl)propyl)-N6-(4-(isoxazol-3-yloxy)but-2-ynyl)-N1,N1,N6,N6-tetramethylhexane-1,6-diaminium dibromide
Molecular formula	C28H40Br2N4O4
IUPAC name	6-[dimethyl-[4-(1,2-oxazol-3-yloxy)but-2-ynyl]azaniumyl]hexyl-[3-(1,3-dioxoisoindol-2-yl)propyl]-dimethylazanium;dibromide
Molecular weight	656.46
Hydrogen bond acceptor	7
Hydrogen bond donor	0
XlogP	None
Synonyms	CHEMBL382846
Inchi Key	BXBQGCJIUWCZHF-UHFFFAOYSA-L
Inchi ID	InChI=1S/C28H40N4O4.2BrH/c1-31(2,20-11-12-22-35-26-16-23-36-29-26)18-9-5-6-10-19-32(3,4)21-13-17-30-27(33)24-14-7-8-15-25(24)28(30)34;;/h7-8,14-16,23H,5-6,9-10,13,17-22H2,1-4H3;2*1H/q+2;;/p-2
PubChem CID	11505652
ChEMBL	CHEMBL382846
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
Intrinsic activity	0.0 -	PMID16392821	ChEMBL
pKb	5.6 -	PMID16392821	ChEMBL

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