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GPCR

Name	Alpha-2B adrenergic receptor
Species	Homo sapiens (Human)
Gene	ADRA2B
Synonym	alpha2-C2 alpha2B alpha2B-adrenoceptor Alpha-2BAR alpha-2B adrenoreceptor Alpha-2B adrenoceptor alpha-2B adrenergic receptor Alpha-2 adrenergic receptor subtype C2 adrenergic receptor Adrenergic alpha2B- receptor class III ADRA2RL1 ADRA2L1 Adra-2b [ Show all ]
Disease	Neuropathic pain Alcohol use disorders
Length	450
Amino acid sequence	MDHQDPYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGSFFAPCLIMILVYLRIYLIAKRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASVASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEEEEEEEEEEECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRILCRPWTQTAW
UniProt	P18089
Protein Data Bank	N/A
GPCR-HGmod model	P18089
3D structure model	This predicted structure model is from GPCR-EXP P18089.
BioLiP	N/A
Therapeutic Target Database	T41580
ChEMBL	CHEMBL1942
IUPHAR	26
DrugBank	BE0000572

Ligand

Name	terazosin
Molecular formula	C19H25N5O4
IUPAC name	[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone
Molecular weight	387.44
Hydrogen bond acceptor	8
Hydrogen bond donor	1
XlogP	1.4
Synonyms	MLS001201836 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)-piperazine NCGC00025191-03 4097AH SAM002589982 6,7-dimethoxy-2-{4-[(oxolan-2-yl)carbonyl]piperazin-1-yl}quinazolin-4-amine Terazosin (INN) Abbott-45975 Terazosinum BPBio1_000840 [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl](tetrahydrofuran-2-yl)methanone DTXSID3023639 HMS3259F04 L000692 NC00689 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]piperazine Prestwick0_000751 6,7-bis(methyloxy)-2-[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]quinazolin-4-amine SPBio_002701 70024-40-7 (mono-hydrochloride, dihydrate) Terazosin [INN:BAN] AKOS005266642 VA11839 BSPBio_000762 CS-2429 FT-0630739 HY-B0371 MCULE-4030111564 NCGC00016026-08 141269-44-5 Prestwick3_000751 6,7-Dimethoxy-2-[4-(tetrahydro-2-furanylcarbonyl)-1-piperazinyl]-4-quinazolinamine # Terazosabb (TN) A-45975 Terazosine BDBM50033111 Z1172269406 CCG-205212 HMS2090P21 Hytrin (TN) MFCD00467965 MLS006011889 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine Opera_ID_1910 SCHEMBL6528 63074-08-8 (hydrochloride) terazosin a AC-11120 Terazosinum [INN-Latin] BRD-A22256192-003-03-7 [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(oxolan-2-yl)methanone CHEMBL611 Flumarc HMS3369P14 Lopac0_001138 NCGC00016026-04 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)4-[(tetrahydro-2-furanyl)carbonyl]piperazine Prestwick1_000751 6,7-dimethoxy-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]-3,4-dihydroquinazolin-4-imine STK567029 Terazosina AN-38972 Vasomet C07127 D08569 GTPL7302 Hytracin MET029 MLS000069703 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)piperazine NCGC00016026-11 141269-45-6 REGID_for_CID_5401 6,7-dimethoxy-2-[4-(tetrahydrofuran-2-ylcarbonyl)piperazin-1-yl]quinazolin-4-amine Abbott 45975 Terazosine [INN-French] Blavin [4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-tetrahydrofuran-2-yl-methanone CHEBI:9445 DB01162 HMS2232N21 KB-147102 MolPort-001-684-489 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(tetrahydro-2-furoyl)piperazine Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-((tetrahydro-2-furanyl)carbonyl)- 590T647 SMR000058309 63590-64-7 Terazosin HCl AC1L1K9W Trazosin HCl BRD-A22256192-003-14-4 CPD000058309 Fosfomic HMS3371E20 LS-110234 (4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(tetrahydrofuran-2-yl)methanone NCGC00016026-05 1-(4-amino-6,7-dimethoxyquinazolin-2-yl)-4-[[(2RS)-2,3,4,5-tetrahydrofuran-2-yl]carbonyl]piperazine Prestwick2_000751 6,7-dimethoxy-2-[4-(oxolane-2-carbonyl)piperazin-1-yl]quinazolin-4-amine Terazosabb A 45975 Terazosina [INN-Spanish] BBL010743 VCKUSRYTPJJLNI-UHFFFAOYSA-N C19H25N5O4 D0P9RF H963 Hytrin Methanone, [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](tetrahydro-2-furanyl)- [ Show all ]
Inchi Key	VCKUSRYTPJJLNI-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H25N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22)
PubChem CID	5401
ChEMBL	CHEMBL611
IUPHAR	7302
BindingDB	50033111
DrugBank	DB01162
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	428.0 nM	DrugMatrix in vitro pharmacology data	ChEMBL
Ki	26.0 nM	PMID7752182	BindingDB,ChEMBL
Ki	30.9 nM	PMID9651170	ChEMBL
Ki	195.0 nM	DrugMatrix in vitro pharmacology data	ChEMBL
Ki	418.0 nM	PMID7658428	BindingDB,ChEMBL

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