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Name | P2Y purinoceptor 2 |
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Species | Homo sapiens (Human) |
Gene | P2RY2 |
Synonym | Purinergic receptor purinergic receptor P2Y P2Y2 receptor P2Y2 P2Y purinoceptor 2 [ Show all ] |
Disease | Dry eye disease Constipation Cystic fibrosis Lung cancer |
Length | 377 |
Amino acid sequence | MAADLGPWNDTINGTWDGDELGYRCRFNEDFKYVLLPVSYGVVCVPGLCLNAVALYIFLCRLKTWNASTTYMFHLAVSDALYAASLPLLVYYYARGDHWPFSTVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLRSLRWGRARYARRVAGAVWVLVLACQAPVLYFVTTSARGGRVTCHDTSAPELFSRFVAYSSVMLGLLFAVPFAVILVCYVLMARRLLKPAYGTSGGLPRAKRKSVRTIAVVLAVFALCFLPFHVTRTLYYSFRSLDLSCHTLNAINMAYKVTRPLASANSCLDPVLYFLAGQRLVRFARDAKPPTGPSPATPARRRLGLRRSDRTDMQRIEDVLGSSEDSRRTESTPAGSENTKDIRL |
UniProt | P41231 |
Protein Data Bank | N/A |
GPCR-HGmod model | P41231 |
3D structure model | This predicted structure model is from GPCR-EXP P41231. |
BioLiP | N/A |
Therapeutic Target Database | T93515 |
ChEMBL | CHEMBL4398 |
IUPHAR | 324 |
DrugBank | BE0002401 |
Name | CHEMBL239814 |
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Molecular formula | C14H22NO14P3 |
IUPAC name | [[(2R,3S,4R,5R)-3,4-dihydroxy-5-(1-oxo-5,6,7,8-tetrahydroisoquinolin-2-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate |
Molecular weight | 521.244 |
Hydrogen bond acceptor | 14 |
Hydrogen bond donor | 6 |
XlogP | -4.0 |
Synonyms | ({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(1-oxo-1,2,5,6,7,8-hexahydroisoquinolin-2-yl)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid BDBM50195827 SCHEMBL6800439 |
Inchi Key | BXYVFXVHWLQNDH-HKUMRIAESA-N |
Inchi ID | InChI=1S/C14H22NO14P3/c16-11-10(7-26-31(22,23)29-32(24,25)28-30(19,20)21)27-14(12(11)17)15-6-5-8-3-1-2-4-9(8)13(15)18/h5-6,10-12,14,16-17H,1-4,7H2,(H,22,23)(H,24,25)(H2,19,20,21)/t10-,11-,12-,14-/m1/s1 |
PubChem CID | 44439745 |
ChEMBL | CHEMBL239814 |
IUPHAR | N/A |
BindingDB | 50195827 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 55.0 nM | PMID17011188 | BindingDB,ChEMBL |
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