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Name | Prostaglandin E2 receptor EP4 subtype |
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Species | Homo sapiens (Human) |
Gene | PTGER4 |
Synonym | Prostanoid EP4 receptor PGE2 receptor EP4 subtype PGE receptor EP4 subtype EP4 receptor EP2 |
Disease | Ulcerative colitis Glaucoma Inflammatory disease Migraine Osteoarthritis [ Show all ] |
Length | 488 |
Amino acid sequence | MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI |
UniProt | P35408 |
Protein Data Bank | 5ywy, 5yhl |
GPCR-HGmod model | P35408 |
3D structure model | This structure is from PDB ID 5ywy. |
BioLiP | BL0434347, BL0434289 |
Therapeutic Target Database | T18876 |
ChEMBL | CHEMBL1836 |
IUPHAR | 343 |
DrugBank | BE0003522 |
Name | cloprostenol |
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Molecular formula | C22H29ClO6 |
IUPAC name | (Z)-7-[(1R,2R,3R,5S)-2-[(E,3R)-4-(3-chlorophenoxy)-3-hydroxybut-1-enyl]-3,5-dihydroxycyclopentyl]hept-5-enoic acid |
Molecular weight | 424.918 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 4 |
XlogP | 2.7 |
Synonyms | (+)-Cloprostenol 100786-10-5 5-Heptenoic acid, 7-((1R,2R,3R,5S)-2-((1E,3R)-4-(3-chlorophenoxy)-3-hydroxy-1-butenyl)-3,5-dihydroxycyclopentyl)-, (5Z)-rel- 87347-50-0 BRD-K17850764-236-03-6 [ Show all ] |
Inchi Key | VJGGHXVGBSZVMZ-QIZQQNKQSA-N |
Inchi ID | InChI=1S/C22H29ClO6/c23-15-6-5-7-17(12-15)29-14-16(24)10-11-19-18(20(25)13-21(19)26)8-3-1-2-4-9-22(27)28/h1,3,5-7,10-12,16,18-21,24-26H,2,4,8-9,13-14H2,(H,27,28)/b3-1-,11-10+/t16-,18-,19-,20+,21-/m1/s1 |
PubChem CID | 5311053 |
ChEMBL | CHEMBL37853 |
IUPHAR | 1894 |
BindingDB | 50085910 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | <10000.0 nM | PMID10715159 | BindingDB,ChEMBL |
Ki | 9137.0 nM | PMID10634944 | BindingDB |
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