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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Gastrin-releasing peptide receptor
Species	Mus musculus (Mouse)
Gene	Grpr
Synonym	BB2 BB2 receptor Gastrin-releasing peptide receptor GRP-preferring bombesin receptor GRP-R
Disease	N/A for non-human GPCRs
Length	384
Amino acid sequence	MAPNNCSHLNLDVDPFLSCNDTFNQSLSPPKMDNWFHPGFIYVIPAVYGLIIVIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASKYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAALIWIVSMLLAIPEAVFSDLHPFHVKDTNQTFISCAPYPHSNELHPKIHSMASFLVFYVIPLAIISVYYYFIARNLIQSAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLHFVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLMNRSHSTGRSTTCMTSFKSTNPSATFSLINRNICHEGYV
UniProt	P21729
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3596
IUPHAR	39
DrugBank	N/A

Ligand

Name	CHEMBL2369376
Molecular formula	C44H64N12O8
IUPAC name	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-N-[(2S)-1-[[(2S)-1-[[(2S)-1-ethoxy-4-methylpentan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]-3-methylbutanamide
Molecular weight	889.072
Hydrogen bond acceptor	10
Hydrogen bond donor	10
XlogP	1.5
Synonyms	BDBM50012305
Inchi Key	VJMHXMWDFCWPNU-QOZRXYRLSA-N
Inchi ID	InChI=1S/C44H64N12O8/c1-9-64-21-32(14-24(2)3)53-42(61)37(17-31-20-46-23-49-31)54-39(58)26(6)51-44(63)38(25(4)5)56-40(59)27(7)50-41(60)35(15-29-18-47-34-13-11-10-12-33(29)34)55-43(62)36(52-28(8)57)16-30-19-45-22-48-30/h10-13,18-20,22-27,32,35-38,47H,9,14-17,21H2,1-8H3,(H,45,48)(H,46,49)(H,50,60)(H,51,63)(H,52,57)(H,53,61)(H,54,58)(H,55,62)(H,56,59)/t26-,27-,32-,35-,36-,37-,38-/m0/s1
PubChem CID	15745501
ChEMBL	CHEMBL2369376
IUPHAR	N/A
BindingDB	50012305
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<300.0 nM	PMID2066982	ChEMBL
IC50	5.0 nM	PMID2066982	BindingDB
IC50	410.0 nM	PMID2066982	BindingDB,ChEMBL

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