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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Type-2 angiotensin II receptor
Species	Rattus norvegicus (Rat)
Gene	Agtr2
Synonym	angiotensin II receptor, type 2 MRX88 Agtr2 AT2R AT2-R AT2 receptor angiotensin II receptor angiotensin receptor 2 Angiotensin II type-2 receptor angiotensin II type 2 receptor AT2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	363
Amino acid sequence	MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDTFVS
UniProt	P35351
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL257
IUPHAR	35
DrugBank	N/A

Ligand

Name	CHEMBL59728
Molecular formula	C28H34N4O8S
IUPAC name	methyl 3-[[4-[2-(butoxycarbonylsulfamoyl)phenyl]-2-nitrophenyl]methyl]-5-ethyl-2-propylimidazole-4-carboxylate
Molecular weight	586.66
Hydrogen bond acceptor	9
Hydrogen bond donor	1
XlogP	5.7
Synonyms	BDBM50283012 3-(2''-Butyloxycarbonylsulfamoyl-3-nitro-biphenyl-4-ylmethyl)-5-ethyl-2-propyl-3H-imidazole-4-carboxylic acid methyl ester
Inchi Key	BYGLUGHFELDJQW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C28H34N4O8S/c1-5-8-16-40-28(34)30-41(37,38)24-13-10-9-12-21(24)19-14-15-20(23(17-19)32(35)36)18-31-25(11-6-2)29-22(7-3)26(31)27(33)39-4/h9-10,12-15,17H,5-8,11,16,18H2,1-4H3,(H,30,34)
PubChem CID	44303459
ChEMBL	CHEMBL59728
IUPHAR	N/A
BindingDB	50283012
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	20.0 nM	, Bioorg. Med. Chem. Lett., (1994) 4:16:2011	BindingDB,ChEMBL

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