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GPCR

NameG-protein coupled receptor 35
SpeciesMus musculus (Mouse)
GeneGpr35
SynonymG-protein coupled receptor 3
GPR35
KYNA receptor
Kynurenic acid receptor
DiseaseN/A for non-human GPCRs
Length307
Amino acid sequenceMNSTTCNSTLTWPASVNNFFIIYSALLLVLGLLLNSVALWVFCYRMHQWTETRIYMTNLAVADLCLLCSLPFVLYSLKYSSSDTPVCQLSQGIYLANRYMSISLVTAIAVDRYVAVRHPLRARELRSPRQAAAVCVALWVIVVTSLVVRWRLGMQEGGFCFSSQTRRNFSTTAFSLLGFYLPLAIVVFCSLQVVTVLSRRPAADVGQAEATQKATHMVWANLAVFVICFLPLHVVLTVQVSLNLNTCAARDTFSRALSITGKLSDTNCCLDAICYYYMAREFQEASKPATSSNTPHKSQDSQILSLT
UniProtQ9ES90
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2390813
IUPHAR102
DrugBankN/A

Ligand

NameCROMOLYN SODIUM
Molecular formulaC23H14Na2O11
IUPAC namedisodium;5-[3-(2-carboxylato-4-oxochromen-5-yl)oxy-2-hydroxypropoxy]-4-oxochromene-2-carboxylate
Molecular weight512.334
Hydrogen bond acceptor11
Hydrogen bond donor1
XlogPNone
SynonymsDinatrium salz von 1,3-bis-(2-carboxychromon-5-yloxy)-2-hydroxypropan [German]
s1911
disodium 5-[3-(2-carboxylato-4-oxochromen-5-yl)oxy-2-hydroxypropoxy]-4-oxochromene-2-carboxylate
1,3-Di(2-carboxy-4-oxochromen-5-yloxy)propan-2-ol
DSSTox_RID_80311
[ Show all ]
Inchi KeyVLARUOGDXDTHEH-UHFFFAOYSA-L
Inchi IDInChI=1S/C23H16O11.2Na/c24-11(9-31-14-3-1-5-16-20(14)12(25)7-18(33-16)22(27)28)10-32-15-4-2-6-17-21(15)13(26)8-19(34-17)23(29)30;;/h1-8,11,24H,9-10H2,(H,27,28)(H,29,30);;/q;2*+1/p-2
PubChem CID27503
ChEMBLCHEMBL74
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.
Partition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
EC504840.0 nMPMID23713606ChEMBL
Emax102.0 %PMID23713606ChEMBL

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