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GPCR

NameMetabotropic glutamate receptor 3
SpeciesHomo sapiens (Human)
GeneGRM3
SynonymGPRC1C
mGluR3
mGlu3 receptor
glutamate receptor
DiseaseAlzheimer disease; Major depressive disorder
Anxiety disorder
Schizophrenia
Length879
Amino acid sequenceMKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLAEKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLHLNRFSVSGTGTTYSQSSASTYVPTVCNGREVLDSTTSSL
UniProtQ14832
Protein Data Bank3sm9, 6b7h, 4xar, 5cnk, 5cnm
GPCR-HGmod modelN/A
3D structure modelThis structure is from PDB ID 3sm9.
BioLiPBL0324562, BL0307715, BL0204618, BL0324563, BL0412294, BL0412295, BL0324561
Therapeutic Target DatabaseT02719
ChEMBLCHEMBL2888
IUPHAR291
DrugBankN/A

Ligand

NameBDBM50388941
Molecular formulaC16H13N3O3
IUPAC name(1aS,7aS)-7-nitroso-N-pyridin-2-yl-7,7a-dihydro-1H-cyclopropa[b]chromene-1a-carboxamide
Molecular weight295.298
Hydrogen bond acceptor5
Hydrogen bond donor1
XlogP1.4
SynonymsN/A
Inchi KeyBYHNFRUAWWJVKC-IPGJNNTFSA-N
Inchi IDInChI=1S/C16H13N3O3/c20-15(18-13-7-3-4-8-17-13)16-9-11(16)14(19-21)10-5-1-2-6-12(10)22-16/h1-8,11,14H,9H2,(H,17,18,20)/t11-,14?,16-/m0/s1
PubChem CID91929760
ChEMBLN/A
IUPHARN/A
BindingDB50388941
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50<30000.0 nMPMID22148748BindingDB

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