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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Rattus norvegicus (Rat)
Gene	Mchr1
Synonym	SLC-1 MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 somatostatin receptor-like protein [ Show all ]
Disease	N/A for non-human GPCRs
Length	353
Amino acid sequence	MDLQTSLLSTGPNASNISDGQDNLTLPGSPPRTGSVSYINIIMPSVFGTICLLGIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMTIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
UniProt	P97639
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1075228
IUPHAR	280
DrugBank	N/A

Ligand

Name	CHEMBL216576
Molecular formula	C29H26F3N3O
IUPAC name	N-[2-(3-phenylpyrrolidin-1-yl)quinolin-6-yl]-3-[4-(trifluoromethyl)phenyl]propanamide
Molecular weight	489.542
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	6.5
Synonyms	BDBM50193691 N-(2-(3-phenylpyrrolidin-1-yl)quinolin-6-yl)-3-(4-(trifluoromethyl)phenyl)propanamide
Inchi Key	BYTPBLLHHBOSEQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C29H26F3N3O/c30-29(31,32)24-10-6-20(7-11-24)8-15-28(36)33-25-12-13-26-22(18-25)9-14-27(34-26)35-17-16-23(19-35)21-4-2-1-3-5-21/h1-7,9-14,18,23H,8,15-17,19H2,(H,33,36)
PubChem CID	44417917
ChEMBL	CHEMBL216576
IUPHAR	N/A
BindingDB	50193691
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	1770.0 nM	PMID16919456	ChEMBL

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