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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
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GPCR

Name	Thyrotropin-releasing hormone receptor
Species	Mus musculus (Mouse)
Gene	Trhr
Synonym	Thyroliberin receptor TRH receptor TRH-R TRH-R1 TRH1 receptor
Disease	N/A for non-human GPCRs
Length	393
Amino acid sequence	MENDTVSEMNQTELQPQAAVALEYQVVTILLVVIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLNISTYKNAVVVSCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKMWKNDSIHQNKNLNLNATNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKAANYSVALNYSVIKESDRFSTELEDITVTDTYVSTTKVSFDDTCLASEN
UniProt	P21761
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2467
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL181118
Molecular formula	C20H19N3O3
IUPAC name	N-(2-methylpropyl)-1-(3-nitrophenyl)isoquinoline-3-carboxamide
Molecular weight	349.39
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	4.5
Synonyms	N/A
Inchi Key	VPFOKVXTMNUAPE-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H19N3O3/c1-13(2)12-21-20(24)18-11-14-6-3-4-9-17(14)19(22-18)15-7-5-8-16(10-15)23(25)26/h3-11,13H,12H2,1-2H3,(H,21,24)
PubChem CID	44390469
ChEMBL	CHEMBL181118
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Competition	26.0 %	PMID15664847	ChEMBL
Competition	61.0 %	PMID15664847	ChEMBL

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