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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Kappa-type opioid receptor
Species	Cavia porcellus (Guinea pig)
Gene	OPRK1
Synonym	K-OR-1 KOR-1
Disease	N/A for non-human GPCRs
Length	380
Amino acid sequence	MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
UniProt	P41144
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3952
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	U50488
Molecular formula	C19H26Cl2N2O
IUPAC name	2-(3,4-dichlorophenyl)-N-methyl-N-[(1R,2R)-2-pyrrolidin-1-ylcyclohexyl]acetamide
Molecular weight	369.33
Hydrogen bond acceptor	2
Hydrogen bond donor	0
XlogP	4.4
Synonyms	3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer Benzeneacetamide, 3,4-dichloro-N-methyl-N-(2-(1-pyrrolidinyl)cyclohexyl)-, trans- Lopac-U-110 SCHEMBL332193 U-50488H 83913-05-7 CHEBI:73358 LS-28505 trans-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-benzeneacetamide 2-(3,4-dichlorophenyl)-N-methyl-N-[(1R,2R)-2-pyrrolidin-1-ylcyclohexyl]acetamide AC1MI0XE D0J1PJ NCGC00163181-01 U-50,488 ZINC643032 C11796 Lopac-U-111 trans-(+/-)-3,4-dichloro-n-methyl-n-(2-[1-pyrrolidinyl]cyclohexyl)benzeneacetamide U50,488 2-(3,4-dichlorophenyl)-N-methyl-N-[(1R,2R)-2-(1-pyrrolidinyl)cyclohexyl]acetamide 83913-06-8 NCGC00016071-01 U 50,488 U50488H 2-(3,4-dichlorophenyl)-N-methyl-N-[(1R,2R)-2-pyrrolidin-1-ylcyclohexyl]ethanamide BDBM50000296 GTPL1652 NIH 10533 U-50488 (+)-U-50488 67198-13-4 CCG-205330 Lopac0_001256 trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]-benzeneacetamide U50,488H 2-(3,4-dichlorophenyl)-N-methyl-N-[(1R,2R)-2-(pyrrolidin-1-yl)cyclohexyl]acetamide A843453 CHEMBL441765 NCGC00016071-02 U 50488 UM 1382 [ Show all ]
Inchi Key	VQLPLYSROCPWFF-QZTJIDSGSA-N
Inchi ID	InChI=1S/C19H26Cl2N2O/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23/h8-9,12,17-18H,2-7,10-11,13H2,1H3/t17-,18-/m1/s1
PubChem CID	3036289
ChEMBL	CHEMBL441765
IUPHAR	1652
BindingDB	50000296
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Control	38.0 %	PMID1319495	ChEMBL
Control	105.0 %	PMID1319495	ChEMBL
Control	109.0 %	PMID1319495	ChEMBL
IC50	0.303 nM	PMID18990576	BindingDB,ChEMBL
IC50	1.12 nM	PMID18829333	BindingDB,ChEMBL
IC50	1.14 nM	PMID18337104	BindingDB,ChEMBL
IC50	95.5 nM	PMID1659636	ChEMBL
IC50	96.0 nM	PMID1846918, PMID1659636	BindingDB,ChEMBL
Ke	0.031 nM	PMID18829333	ChEMBL
Ki	0.31 nM	PMID20441176	BindingDB
Ki	0.31 nM	PMID20441176, PMID21481987	ChEMBL
Ki	0.34 nM	PMID24856182, PMID25062506	BindingDB
Ki	0.34 nM	PMID24856182, PMID25062506	ChEMBL
Ki	0.36 nM	PMID11591513, PMID10633042	BindingDB
Ki	0.36 nM	PMID11591513, PMID10633042	ChEMBL
Ki	0.49 nM	PMID17420073, PMID11495592	BindingDB,ChEMBL
Ki	0.49 nM	PMID11495592	BindingDB
Ki	0.89 nM	PMID10841791	BindingDB,ChEMBL
Ki	0.912 nM	PMID8632410	ChEMBL
Ki	0.97 nM	PMID1846921	BindingDB
Ki	0.97 nM	PMID1846921	ChEMBL
Ki	1.1 nM	PMID20599386	BindingDB
Ki	1.14 nM	PMID20599386	ChEMBL
Ki	1.16 nM	PMID1361580	ChEMBL
Ki	1.2 nM	PMID1361580	BindingDB
Ki	1.5 nM	PMID25062506	BindingDB,ChEMBL
Ki	1.67 nM	PMID25147605	ChEMBL
Ki	1.7 nM	PMID25147605	BindingDB
Ki	2.2 nM	PMID1652025, PMID1323679	BindingDB,ChEMBL
Ki	5.0 nM	PMID10956208	BindingDB
Ki	5.01 nM	PMID10956208	ChEMBL
Ki	10.0 nM	PMID2832603, PMID1846919	BindingDB,ChEMBL
Ki	15.0 nM	PMID1319495	BindingDB,ChEMBL
Ki	16.5 nM	PMID8390575	ChEMBL
Ki	17.0 nM	PMID8390575	BindingDB
Ki	20.5 nM	PMID8390575	ChEMBL
Ki	21.0 nM	PMID8390575	BindingDB
Ki	109.0 nM	PMID2547074	BindingDB,ChEMBL
Ki	204.0 nM	PMID8390575	BindingDB,ChEMBL
Ki	299.0 nM	PMID2547074	BindingDB,ChEMBL
Ki	1298.0 nM	PMID2547074	BindingDB,ChEMBL
Ratio	88.0 -	PMID1846919	ChEMBL