You can:
Name | Mu-type opioid receptor |
---|---|
Species | Cavia porcellus (Guinea pig) |
Gene | OPRM1 |
Synonym | M-OR-1 MOR-1 |
Disease | N/A for non-human GPCRs |
Length | 98 |
Amino acid sequence | YTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKTVNVCNWI |
UniProt | P97266 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4354 |
IUPHAR | N/A |
DrugBank | N/A |
Name | U50488 |
---|---|
Molecular formula | C19H26Cl2N2O |
IUPAC name | 2-(3,4-dichlorophenyl)-N-methyl-N-[(1R,2R)-2-pyrrolidin-1-ylcyclohexyl]acetamide |
Molecular weight | 369.33 |
Hydrogen bond acceptor | 2 |
Hydrogen bond donor | 0 |
XlogP | 4.4 |
Synonyms | 2-(3,4-dichlorophenyl)-N-methyl-N-[(1R,2R)-2-pyrrolidin-1-ylcyclohexyl]ethanamide BDBM50000296 GTPL1652 NIH 10533 U-50488 [ Show all ] |
Inchi Key | VQLPLYSROCPWFF-QZTJIDSGSA-N |
Inchi ID | InChI=1S/C19H26Cl2N2O/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23/h8-9,12,17-18H,2-7,10-11,13H2,1H3/t17-,18-/m1/s1 |
PubChem CID | 3036289 |
ChEMBL | CHEMBL441765 |
IUPHAR | 1652 |
BindingDB | 50000296 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Control | 78.0 % | PMID1319495 | ChEMBL |
Control | 91.0 % | PMID1319495 | ChEMBL |
Control | 101.0 % | PMID1319495 | ChEMBL |
Ki | 206.0 nM | PMID1361580 | BindingDB,ChEMBL |
Ki | 220.0 nM | PMID11591513, PMID10633042 | BindingDB,ChEMBL |
Ki | 616.0 nM | PMID1652025, PMID1323679, PMID1846921 | BindingDB,ChEMBL |
Ki | 825.0 nM | PMID1319495 | BindingDB,ChEMBL |
Ki | 880.0 nM | PMID2832603, PMID1846919 | BindingDB,ChEMBL |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218