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GPCR

NameN-formyl peptide receptor 3
SpeciesHomo sapiens (Human)
GeneFPR3
SynonymFMLP-related receptor II
Lxa4r
LXA4-R
FPRL2
Fprl1
[ Show all ]
DiseaseN/A
Length353
Amino acid sequenceMETNFSIPLNETEEVLPEPAGHTVLWIFSLLVHGVTFVFGVLGNGLVIWVAGFRMTRTVNTICYLNLALADFSFSAILPFRMVSVAMREKWPFGSFLCKLVHVMIDINLFVSVYLITIIALDRCICVLHPAWAQNHRTMSLAKRVMTGLWIFTIVLTLPNFIFWTTISTTNGDTYCIFNFAFWGDTAVERLNVFITMAKVFLILHFIIGFSVPMSIITVCYGIIAAKIHRNHMIKSSRPLRVFAAVVASFFICWFPYELIGILMAVWLKEMLLNGKYKIILVLINPTSSLAFFNSCLNPILYVFMGRNFQERLIRSLPTSLERALTEVPDSAQTSNTDTTSASPPEETELQAM
UniProtP25089
Protein Data BankN/A
GPCR-HGmod modelP25089
3D structure modelThis predicted structure model is from GPCR-EXP P25089.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLN/A
IUPHAR224
DrugBankN/A

Ligand

NameCHEMBL2391447
Molecular formulaC22H21BrN4O4
IUPAC name2-[4-acetyl-5-(4-methoxyanilino)-3-methyl-6-oxopyridazin-1-yl]-N-(4-bromophenyl)acetamide
Molecular weight485.338
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP3.5
SynonymsBDBM50435896
Inchi KeyVRBJPKODQPKKFN-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H21BrN4O4/c1-13-20(14(2)28)21(25-17-8-10-18(31-3)11-9-17)22(30)27(26-13)12-19(29)24-16-6-4-15(23)5-7-16/h4-11,25H,12H2,1-3H3,(H,24,29)
PubChem CID71698365
ChEMBLCHEMBL2391447
IUPHARN/A
BindingDB50435896
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC50<50000.0 nMPMID23685570BindingDB

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