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GPCR

NameCannabinoid receptor 2
SpeciesRattus norvegicus (Rat)
GeneCnr2
SynonymPeripheral cannabinoid receptor
CB2-R
CB2 receptor
CB2
CB-2
[ Show all ]
DiseaseN/A for non-human GPCRs
Length360
Amino acid sequenceMAGCRELELTNGSNGGLEFNPMKEYMILSDAQQIAVAVLCTLMGLLSALENVAVLYLILSSQRLRRKPSYLFIGSLAGADFLASVIFACNFVIFHVFHGVDSRNIFLLKIGSVTMTFTASVGSLLLTAVDRYLCLCYPPTYKALVTRGRALVALGVMWVLSALISYLPLMGWTCCPSPCSELFPLIPNDYLLGWLLFIAILFSGIIYTYGYVLWKAHQHVASLAEHQDRQVPGIARMRLDVRLAKTLGLVMAVLLICWFPALALMGHSLVTTLSDKVKEAFAFCSMLCLVNSMINPIIYALRSGEIRSAAQHCLTGWKKYLQGLGSEGKEEAPKSSVTETEAEVKTTTGPGSRTPGCSNC
UniProtQ9QZN9
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2470
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL566260
Molecular formulaC17H25N3O2
IUPAC name1-ethyl-N-[5-methyl-4-(morpholin-4-ylmethyl)pyridin-2-yl]cyclopropane-1-carboxamide
Molecular weight303.406
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP1.4
SynonymsSCHEMBL4733628
1-ethyl-N-(5-methyl-4-(morpholinomethyl)pyridin-2-yl)cyclopropanecarboxamide
BDBM50302300
Inchi KeyBZGJXNGJNPKUIC-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H25N3O2/c1-3-17(4-5-17)16(21)19-15-10-14(13(2)11-18-15)12-20-6-8-22-9-7-20/h10-11H,3-9,12H2,1-2H3,(H,18,19,21)
PubChem CID45487781
ChEMBLCHEMBL566260
IUPHARN/A
BindingDB50302300
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC5062.0 nMPMID19736007BindingDB,ChEMBL

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