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GPCR

NameAdenosine receptor A2b
SpeciesRattus norvegicus (Rat)
GeneAdora2b
SynonymA2b
A2B receptor
A2BR
adenosine receptor A2b
DiseaseN/A for non-human GPCRs
Length332
Amino acid sequenceMQLETQDALYVALELVIAALAVAGNVLVCAAVGASSALQTPTNYFLVSLATADVAVGLFAIPFAITISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAVAVDRYLAIRVPLRYKGLVTGTRARGIIAVLWVLAFGIGLTPFLGWNSKDRATSNCTEPGDGITNKSCCPVKCLFENVVPMSYMVYFNFFGCVLPPLLIMMVIYIKIFMVACKQLQHMELMEHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAINCITLFHPALAKDKPKWVMNVAILLSHANSVVNPIVYAYRNRDFRYSFHRIISRYVLCQTDTKGGSGQAGGQSTFSLSL
UniProtP29276
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2592
IUPHAR20
DrugBankN/A

Ligand

Namedopamine
Molecular formulaC8H11NO2
IUPAC name4-(2-aminoethyl)benzene-1,2-diol
Molecular weight153.181
Hydrogen bond acceptor3
Hydrogen bond donor3
XlogP-1.0
Synonyms13510-EP2287162A1
AC1L19S5
13510-EP2298731A1
ASL 279
13510-EP2305260A1
[ Show all ]
Inchi KeyVYFYYTLLBUKUHU-UHFFFAOYSA-N
Inchi IDInChI=1S/C8H11NO2/c9-4-3-6-1-2-7(10)8(11)5-6/h1-2,5,10-11H,3-4,9H2
PubChem CID681
ChEMBLCHEMBL59
IUPHAR940
BindingDB55121
DrugBankDB00988

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki977.0 nMN/ABindingDB
Ki977.24 nMBioorg. Med. Chem. Lett., (1995) 5:20:2371ChEMBL

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