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GPCR

NameHistamine H4 receptor
SpeciesHomo sapiens (Human)
GeneHRH4
SynonymPfi-013
SP9144
HH4R
H4R
H4 receptor
[ Show all ]
DiseaseAllergic rhinitis
Asthma
Inflammatory disease
Rheumatoid arthritis
Length390
Amino acid sequenceMPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
UniProtQ9H3N8
Protein Data BankN/A
GPCR-HGmod modelQ9H3N8
3D structure modelThis predicted structure model is from GPCR-EXP Q9H3N8.
BioLiPN/A
Therapeutic Target DatabaseT26500
ChEMBLCHEMBL3759
IUPHAR265
DrugBankBE0000146

Ligand

NameCHEMBL3220892
Molecular formulaC17H23N5O
IUPAC nameN-[N'-(3-imidazol-1-ylpropyl)carbamimidoyl]-3-phenylbutanamide
Molecular weight313.405
Hydrogen bond acceptor3
Hydrogen bond donor2
XlogP1.7
SynonymsN/A
Inchi KeyAEOZDVJZTYYDHL-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H23N5O/c1-14(15-6-3-2-4-7-15)12-16(23)21-17(18)20-8-5-10-22-11-9-19-13-22/h2-4,6-7,9,11,13-14H,5,8,10,12H2,1H3,(H3,18,20,21,23)
PubChem CID90667434
ChEMBLCHEMBL3220892
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC501000.0 nMMedChemComm, (2014) 5:1:72ChEMBL
Intrinsic activity0.77 -MedChemComm, (2014) 5:1:72ChEMBL

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