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GPCR

NameEndothelin-1 receptor
SpeciesRattus norvegicus (Rat)
GeneEdnra
Synonymendothelin A receptor
Endothelin receptor type A {ECO:0000312|RGD:2535}
ENDOR
endothelin-1 receptor
ET-A
[ Show all ]
DiseaseN/A for non-human GPCRs
Length426
Amino acid sequenceMGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCMLNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSSHKDSMN
UniProtP26684
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4566
IUPHAR219
DrugBankN/A

Ligand

NameCHEMBL26079
Molecular formulaC19H19N3O4S
IUPAC nameN-(3,4-dimethyl-1,2-oxazol-5-yl)-5-(2-oxopyrrolidin-1-yl)naphthalene-1-sulfonamide
Molecular weight385.438
Hydrogen bond acceptor6
Hydrogen bond donor1
XlogP2.7
SynonymsBDBM50034439
SCHEMBL7946232
5-(2-Oxo-pyrrolidin-1-yl)-naphthalene-1-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide
Inchi KeyCADOLIAMGUQADS-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H19N3O4S/c1-12-13(2)20-26-19(12)21-27(24,25)17-9-4-6-14-15(17)7-3-8-16(14)22-11-5-10-18(22)23/h3-4,6-9,21H,5,10-11H2,1-2H3
PubChem CID10385400
ChEMBLCHEMBL26079
IUPHARN/A
BindingDB50034439
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50130.0 nMPMID7731020BindingDB,ChEMBL

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