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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
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GPCR

Name	Bombesin receptor subtype-3
Species	Rattus norvegicus (Rat)
Gene	Brs3
Synonym	bb3 BB3 receptor bombesin like receptor 3 bombesin receptor subtype-3 BRS-3
Disease	N/A for non-human GPCRs
Length	399
Amino acid sequence	MSQRQPQSPNQTLISITNDTETSSSAVSNDTTPKGWTGDNSPGIEALCAIYITYAVIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGKVGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPSNAILKTCAKAGGIWIMAMIFALPEAIFSNVYTFQDPNRNVTFESCNSYPISERLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIAKTVLVLVALFALCWLPNHLLYLYHSFTYESYAEPSDVPFVVTIFSRVLAFSNSCVNPFALYWLSKTFQKHFKAQLCCFKAEQPEPPLGDTPLNNLTVMGRVPATGSAHVSEISVTLFSGSTAKKGEDKV
UniProt	Q8K418
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1075111
IUPHAR	40
DrugBank	N/A

Ligand

Name	CHEMBL1096548
Molecular formula	C18H28N6
IUPAC name	7-(2-methylpropyl)-5-piperidin-1-yl-2,6,8,9-tetrahydropyrazolo[3,4-c][2,7]naphthyridin-1-amine
Molecular weight	328.464
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	3.0
Synonyms	BDBM50317460 7-isobutyl-5-(piperidin-1-yl)-6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c][2,7]naphthyridin-1-amine
Inchi Key	WHAFCYAFXQMIBN-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H28N6/c1-12(2)10-23-9-6-13-14(11-23)18(24-7-4-3-5-8-24)20-17-15(13)16(19)21-22-17/h12H,3-11H2,1-2H3,(H3,19,20,21,22)
PubChem CID	46887948
ChEMBL	CHEMBL1096548
IUPHAR	N/A
BindingDB	50317460
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	61.0 %	PMID20371178	ChEMBL
EC50	10000.0 nM	PMID20371178	BindingDB,ChEMBL

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