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Name | 5-hydroxytryptamine receptor 1D |
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Species | Rattus norvegicus (Rat) |
Gene | Htr1d |
Synonym | 5-HT1D receptor HTRL Htr1db HT1DA Gpcr14 [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 374 |
Amino acid sequence | MSLPNQSLEGLPQEASNRSLNATGAWDPEVLQALRISLVVVLSIITLATVLSNAFVLTTILLTKKLHTPANYLIGSLATTDLLVSILVMPISIAYTTTRTWNFGQILCDIWVSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAAVWAISICISIPPLFWRQATAHEEMSDCLVNTSQISYTIYSTCGAFYIPSILLIILYGRIYVAARSRILNPPSLYGKRFTTAQLITGSAGSSLCSLNPSLHESHTHTVGSPLFFNQVKIKLADSILERKRISAARERKATKTLGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPVIYTVFNEDFRQAFQRVVHFRKAS |
UniProt | P28565 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL5450 |
IUPHAR | 3 |
DrugBank | N/A |
Name | 5-Carboxamidotryptamine |
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Molecular formula | C11H13N3O |
IUPAC name | 3-(2-aminoethyl)-1H-indole-5-carboxamide |
Molecular weight | 203.245 |
Hydrogen bond acceptor | 2 |
Hydrogen bond donor | 3 |
XlogP | -0.6 |
Synonyms | NCGC00015182-03 RTR-033194 [3H]-5-Carboxyamidotryptamine 3-(2-aminoethyl)-1H-indole-5-carboxamide 74885-09-9 [ Show all ] |
Inchi Key | WKZLNEWVIAGNAW-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C11H13N3O/c12-4-3-8-6-14-10-2-1-7(11(13)15)5-9(8)10/h1-2,5-6,14H,3-4,12H2,(H2,13,15) |
PubChem CID | 1809 |
ChEMBL | CHEMBL18840 |
IUPHAR | 4 |
BindingDB | 21392 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 0.37 nM | PMID7984267 | BindingDB |
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