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Name | 5-hydroxytryptamine receptor 1D |
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Species | Sus scrofa (Pig) |
Gene | HTR1D |
Synonym | 5-HT-1D 5-HT1D Serotonin receptor 1D |
Disease | N/A for non-human GPCRs |
Length | 291 |
Amino acid sequence | AMTDLLVSILVMPISIPYTITQTWSFGQLLCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAIVWAISICISIPPLFWRQARAHEEISDCLVNTSQISYTIYSTCGAFYIPSLLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNPSLHEGHSHSAGSPLFFNHVKIKLADSVLERKRISAARERKATKTLGIILGAFIICWLPFFVASLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKVV |
UniProt | P79400 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4105 |
IUPHAR | N/A |
DrugBank | N/A |
Name | CHEMBL103371 |
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Molecular formula | C17H26N4O2S |
IUPAC name | N,N-dimethyl-2-[5-[2-(5-methyl-1,1-dioxo-1,2,5-thiadiazolidin-2-yl)ethyl]-1H-indol-3-yl]ethanamine |
Molecular weight | 350.481 |
Hydrogen bond acceptor | 5 |
Hydrogen bond donor | 1 |
XlogP | 1.6 |
Synonyms | BDBM50422025 SCHEMBL8807317 2-[2-[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]ethyl]-5-methyl-1,2,5-thiadiazolidine 1,1-dioxide |
Inchi Key | CAYIRJBJYNSWEQ-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C17H26N4O2S/c1-19(2)8-7-15-13-18-17-5-4-14(12-16(15)17)6-9-21-11-10-20(3)24(21,22)23/h4-5,12-13,18H,6-11H2,1-3H3 |
PubChem CID | 10315894 |
ChEMBL | CHEMBL103371 |
IUPHAR | N/A |
BindingDB | 50422025 |
DrugBank | N/A |
Structure | ![]() |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 39.81 nM | PMID7932524 | ChEMBL |
IC50 | 40.0 nM | PMID7932524 | BindingDB |
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