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GPCR

NamePyroglutamylated RF-amide peptide receptor
SpeciesHomo sapiens (Human)
GeneQRFPR
SynonymQRFP receptor
peptide p518 receptor
Orexigenic neuropeptide QRFP receptor
GPR103
G-protein coupled receptor 103
[ Show all ]
DiseaseN/A
Length431
Amino acid sequenceMQALNITPEQFSRLLRDHNLTREQFIALYRLRPLVYTPELPGRAKLALVLTGVLIFALALFGNALVFYVVTRSKAMRTVTNIFICSLALSDLLITFFCIPVTMLQNISDNWLGGAFICKMVPFVQSTAVVTEILTMTCIAVERHQGLVHPFKMKWQYTNRRAFTMLGVVWLVAVIVGSPMWHVQQLEIKYDFLYEKEHICCLEEWTSPVHQKIYTTFILVILFLLPLMVMLILYSKIGYELWIKKRVGDGSVLRTIHGKEMSKIARKKKRAVIMMVTVVALFAVCWAPFHVVHMMIEYSNFEKEYDDVTIKMIFAIVQIIGFSNSICNPIVYAFMNENFKKNVLSAVCYCIVNKTFSPAQRHGNSGITMMRKKAKFSLRENPVEETKGEAFSDGNIEVKLCEQTEEKKKLKRHLALFRSELAENSPLDSGH
UniProtQ96P65
Protein Data BankN/A
GPCR-HGmod modelQ96P65
3D structure modelThis predicted structure model is from GPCR-EXP Q96P65.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5852
IUPHAR333
DrugBankN/A

Ligand

NameCHEMBL1802380
Molecular formulaC48H58FN11O9
IUPAC name(2S)-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]-5-(diaminomethylideneamino)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[2-(4-fluorophenyl)acetyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]pentanamide
Molecular weight952.058
Hydrogen bond acceptor11
Hydrogen bond donor11
XlogP0.8
SynonymsBDBM50347857
Inchi KeyWMHJWVACQAWJHH-MQDBWYGVSA-N
Inchi IDInChI=1S/C48H58FN11O9/c49-34-20-18-33(19-21-34)26-40(62)54-27-41(63)55-28-42(64)56-37(24-31-13-6-2-7-14-31)45(67)60-39(29-61)47(69)59-38(25-32-15-8-3-9-16-32)46(68)57-35(17-10-22-53-48(51)52)44(66)58-36(43(50)65)23-30-11-4-1-5-12-30/h1-9,11-16,18-21,35-39,61H,10,17,22-29H2,(H2,50,65)(H,54,62)(H,55,63)(H,56,64)(H,57,68)(H,58,66)(H,59,69)(H,60,67)(H4,51,52,53)/t35-,36-,37-,38-,39-/m0/s1
PubChem CID53363899
ChEMBLCHEMBL1802380
IUPHARN/A
BindingDB50347857
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC50830.0 nMPMID21623631BindingDB,ChEMBL

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