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GPCR

NameC-X-C chemokine receptor type 2
SpeciesHomo sapiens (Human)
GeneCXCR2
Synonymchemokine (C-X-C motif) receptor 2
KC receptor
CD128
IL8RB
IL-8R2
[ Show all ]
DiseaseCystic fibrosis; Chronic obstructive pulmonary disease
Asthma
Cancer
Ischemia-reperfusion injury; Lung transplantation; Graft rejection in heart transplantation
Fungal infections
[ Show all ]
Length360
Amino acid sequenceMEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL
UniProtP25025
Protein Data BankN/A
GPCR-HGmod modelP25025
3D structure modelThis predicted structure model is from GPCR-EXP P25025.
BioLiPN/A
Therapeutic Target DatabaseT56923
ChEMBLCHEMBL2434
IUPHAR69
DrugBankN/A

Ligand

NameCHEMBL220860
Molecular formulaC17H18ClN5O3S
IUPAC name1-[4-chloro-3-(dimethylsulfamoyl)-2-hydroxyphenyl]-3-cyano-2-(2-methylphenyl)guanidine
Molecular weight407.873
Hydrogen bond acceptor6
Hydrogen bond donor3
XlogP3.7
Synonyms6-chloro-3-({(cyanoimino)[(2-methylphenyl)amino]methyl}amino)-2-hydroxy-N,N-dimethylbenzenesulfonamide
BDBM50193986
Inchi KeyCBIODTKCFBGXHU-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H18ClN5O3S/c1-11-6-4-5-7-13(11)21-17(20-10-19)22-14-9-8-12(18)16(15(14)24)27(25,26)23(2)3/h4-9,24H,1-3H3,(H2,20,21,22)
PubChem CID44419439
ChEMBLCHEMBL220860
IUPHARN/A
BindingDB50193986
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5017.0 nMPMID16934456BindingDB,ChEMBL

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