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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
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GPCR

Name	Bombesin receptor subtype-3
Species	Mus musculus (Mouse)
Gene	Brs3
Synonym	bb3 BB3 receptor bombesin like receptor 3 bombesin receptor subtype-3 BRS-3
Disease	N/A for non-human GPCRs
Length	399
Amino acid sequence	MSQRQSQSPNQTLISITNDTETSSSVVSNDTTHKGWTGDNSPGIEALCAIYITYAGIISVGILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGKVGCKVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPPNAILKTCAKAGGIWIVSMIFALPEAIFSNVYTFQDPNRNVTFESCNSYPISERLLQEIHSLLCFLVFYIIPLSIISVYYSLIARTLYKSTLNIPTEEQSHARKQIESRKRIAKTVLVLVALFALCWLPNHLLYLYHSFTYESYANHSDVPFVIIIFSRVLAFSNSCVNPFALYWLSKTFQQHFKAQLCCLKAEQPEPPLGDIPLNNLTVMGRVPATGSAHVSEISVTLFSGSSAKKGEDKV
UniProt	O54798
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1075140
IUPHAR	40
DrugBank	N/A

Ligand

Name	2-(4-(2-(4-(2,2-dimethylbutyl)-1H-imidazol-2-yl)ethyl)phenyl)pyridine
Molecular formula	C22H27N3
IUPAC name	2-[4-[2-[5-(2,2-dimethylbutyl)-1H-imidazol-2-yl]ethyl]phenyl]pyridine
Molecular weight	333.479
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	5.5
Synonyms	2-{2-[4-(pyridin-2-yl)phenyl] ethyl}-5-(2,2-dimethylbutyl)-1h-imidazole C22H27N3 ZINC49070819 0582AA AK120413 D02TPY 2-(4-{2-[5-(2,2-Dimethylbutyl)-1H-imidazol-2-yl]ethyl}phenyl)pyridine Bag-1 KB-222044 1021937-07-4 AKOS016011385 DTXSID60648508 2-[4-[2-[5-(2,2-dimethylbutyl)-1H-imidazol-2-yl]ethyl]phenyl]pyridine BDBM50314969 SCHEMBL3519036 CHEMBL1091720 AX8245829 GTPL6188 [ Show all ]
Inchi Key	WVAKRQOMAINQPU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C22H27N3/c1-4-22(2,3)15-19-16-24-21(25-19)13-10-17-8-11-18(12-9-17)20-7-5-6-14-23-20/h5-9,11-12,14,16H,4,10,13,15H2,1-3H3,(H,24,25)
PubChem CID	25025860
ChEMBL	CHEMBL1091720
IUPHAR	6188
BindingDB	50314969
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	2.8 nM	PMID20219372	BindingDB,ChEMBL
EC50	78.0 nM	PMID20219372	BindingDB,ChEMBL
IC50	6.9 nM	PMID20096642, PMID20219372	BindingDB,IUPHAR,ChEMBL

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