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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Muscarinic acetylcholine receptor M5
Species	Homo sapiens (Human)
Gene	CHRM5
Synonym	M5R M5 receptor cholinergic receptor cholinergic receptor, muscarinic 5
Disease	Urinary incontinence Colitis Dysmenorrhea Irritable bowel syndrome Myasthenia gravis Neurological disease Schizophrenia Stomach ulcer Cognitive disorders Chronic obstructive pulmonary disease Allergic rhinitis Central and peripheral nervous diseases Brain diseases Amnesia [ Show all ]
Length	532
Amino acid sequence	MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPLDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAEKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQLTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPNYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNPNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
UniProt	P08912
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	T79961
ChEMBL	CHEMBL2035
IUPHAR	17
DrugBank	BE0000247, BE0004890

Ligand

Name	4-Damp methiodide
Molecular formula	C21H26INO2
IUPAC name	(1,1-dimethylpiperidin-1-ium-4-yl) 2,2-diphenylacetate;iodide
Molecular weight	451.348
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	None
Synonyms	SCHEMBL3987354 4-DAMP 4-[(2,2-diphenylacetyl)oxy]-1,1-dimethylpiperidin-1-ium iodide C21H26NO2.I FT-0742369 MFCD00078564 SR-01000075326-1 1,1-dimethyl-4-diphenylacetoxypiperidinium iodide 4-DAMP methyliodide AC1MHZ3P CHEBI:73340 HMS3266E10 N,N-dimethyl-4-(diphenylacetoxy)piperidinium iodide Piperidinium, 4-((diphenylacetyl)oxy)-1,1-dimethyl-, iodide 4-((Diphenylacetyl)oxy)-1,1-dimethylpiperidinium iodide 4-DIPHENYLACETOXY-N-METHYL-PIPERIDINE METHIODIDE BN0026 D-104 LP00407 SMR000326843 4-DAMP iodide 4-[(Diphenylacetyl)oxy]-1,1-dimethyl-piperidinium iodide CCG-221711 HMS2234J07 MLS000859984 NCGC00093833-01 SR-01000075326-3 1,1-dimethyl-4-diphenylacetoxypiperidiniumiodide 4-DAMP, >=98% (HPLC) AKOS024458363 HMS3369K06 REGID_for_CID_3014059 4-(2,2-diphenylacetoxy)-1,1-dimethylpiperidinium iodide 4-Diphenylacetoxy-N-methylpiperidine methiodide C-56134 EU-0100407 LS-173781 SR-01000075326 (1,1-dimethylpiperidin-1-ium-4-yl) 2,2-diphenylacetate iodide 81405-11-0 (Parent) CCG-222526 HMS3261A16 MolPort-003-940-940 NCGC00261092-01 Tox21_500407 1952-15-4 4-diphenylacetoxy-1,1-dimethylpiperidinium iodide B6317 CHEMBL76897 J-012645 [ Show all ]
Inchi Key	WWJHRSCUAQPFQO-UHFFFAOYSA-M
Inchi ID	InChI=1S/C21H26NO2.HI/c1-22(2)15-13-19(14-16-22)24-21(23)20(17-9-5-3-6-10-17)18-11-7-4-8-12-18;/h3-12,19-20H,13-16H2,1-2H3;1H/q+1;/p-1
PubChem CID	3014059
ChEMBL	CHEMBL76897
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
IC50	0.32 nM	PMID26988801, PMID27876250	ChEMBL
IC50	0.45 nM	PMID23466604	ChEMBL
IC50	0.8 nM	PMID23582449	ChEMBL
IC50	0.83 nM	PMID18983139	ChEMBL
Ki	0.22 nM	PMID23466604	ChEMBL
Ki	0.42 nM	PMID18983139	ChEMBL
Ki	0.48 nM	PMID24805037	ChEMBL

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