You can:
Name | Muscarinic acetylcholine receptor M2 |
---|---|
Species | Homo sapiens (Human) |
Gene | CHRM2 |
Synonym | cholinergic receptor AChR M2 M2 muscarinic acetylcholine receptor M2 receptor Chrm-2 [ Show all ] |
Disease | Urinary incontinence Heart failure Nausea; Addiction Parkinson's disease Peptic ulcer [ Show all ] |
Length | 466 |
Amino acid sequence | MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR |
UniProt | P08172 |
Protein Data Bank | 5zkc, 4mqs, 4mqt, 5yc8, 5zk3, 5zkb, 5zk8 |
GPCR-HGmod model | P08172 |
3D structure model | This structure is from PDB ID 5zkc. |
BioLiP | BL0433341, BL0433216, BL0263147, BL0263146, BL0263145, BL0433339, BL0433340, BL0433338 |
Therapeutic Target Database | T46185 |
ChEMBL | CHEMBL211 |
IUPHAR | 14 |
DrugBank | BE0000560 |
Name | 4-Damp methiodide |
---|---|
Molecular formula | C21H26INO2 |
IUPAC name | (1,1-dimethylpiperidin-1-ium-4-yl) 2,2-diphenylacetate;iodide |
Molecular weight | 451.348 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 0 |
XlogP | None |
Synonyms | 4-DAMP 4-[(2,2-diphenylacetyl)oxy]-1,1-dimethylpiperidin-1-ium iodide C21H26NO2.I FT-0742369 MFCD00078564 [ Show all ] |
Inchi Key | WWJHRSCUAQPFQO-UHFFFAOYSA-M |
Inchi ID | InChI=1S/C21H26NO2.HI/c1-22(2)15-13-19(14-16-22)24-21(23)20(17-9-5-3-6-10-17)18-11-7-4-8-12-18;/h3-12,19-20H,13-16H2,1-2H3;1H/q+1;/p-1 |
PubChem CID | 3014059 |
ChEMBL | CHEMBL76897 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | Partition coefficient log P of this ligand is not available. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 55.0 nM | PMID23403082 | ChEMBL |
Inhibition | -2.0 % | PMID23403082 | ChEMBL |
Kb | 8.51 nM | PMID10571164 | ChEMBL |
Kd | 2.692 nM | Bioorg. Med. Chem. Lett., (1995) 5:20:2325 | ChEMBL |
Ki | 23.0 nM | PMID23403082 | ChEMBL |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218