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GPCR

Name5-hydroxytryptamine receptor 1D
SpeciesSus scrofa (Pig)
GeneHTR1D
Synonym5-HT-1D
5-HT1D
Serotonin receptor 1D
DiseaseN/A for non-human GPCRs
Length291
Amino acid sequenceAMTDLLVSILVMPISIPYTITQTWSFGQLLCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAAAMIAIVWAISICISIPPLFWRQARAHEEISDCLVNTSQISYTIYSTCGAFYIPSLLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNPSLHEGHSHSAGSPLFFNHVKIKLADSVLERKRISAARERKATKTLGIILGAFIICWLPFFVASLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKVV
UniProtP79400
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4105
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL53467
Molecular formulaC14H18N6
IUPAC nameN,N-dimethyl-2-[5-(tetrazol-2-ylmethyl)-1H-indol-3-yl]ethanamine
Molecular weight270.34
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP1.8
SynonymsN,N-Dimethyl-2-[5-(1,2,3,4-tetrazol-2-ylmethyl)-1H-indol-3-yl]ethylamine
N,N-Dimethyl-5-(2H-tetrazol-2-ylmethyl)-1H-indole-3-(ethanamine)
BDBM50407359
SCHEMBL8783747
CCDMZRADLKWXMG-UHFFFAOYSA-N
Inchi KeyCCDMZRADLKWXMG-UHFFFAOYSA-N
Inchi IDInChI=1S/C14H18N6/c1-19(2)6-5-12-8-15-14-4-3-11(7-13(12)14)9-20-17-10-16-18-20/h3-4,7-8,10,15H,5-6,9H2,1-2H3
PubChem CID10355779
ChEMBLCHEMBL53467
IUPHARN/A
BindingDB50407359
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC5039.81 nMPMID7752204BindingDB,ChEMBL

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