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GPCR

NameThyrotropin-releasing hormone receptor
SpeciesHomo sapiens (Human)
GeneTRHR
SynonymThyroliberin receptor
TRH receptor
TRH-R
TRH-R1
TRH1 receptor
DiseaseUnspecified
Pain
Neurodegenerative disease
Endocrine disease
Cognitive disorders
[ Show all ]
Length398
Amino acid sequenceMENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSVALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS
UniProtP34981
Protein Data BankN/A
GPCR-HGmod modelP34981
3D structure modelThis predicted structure model is from GPCR-EXP P34981.
BioLiPN/A
Therapeutic Target DatabaseT77796
ChEMBLCHEMBL1810
IUPHAR363
DrugBankBE0008659

Ligand

NameMLS000698167
Molecular formulaC22H24IN3O
IUPAC name[6-[(E)-2-(1H-indol-3-yl)ethenyl]-1-methylpyridin-1-ium-3-yl]-piperidin-1-ylmethanone;iodide
Molecular weight473.358
Hydrogen bond acceptor2
Hydrogen bond donor1
XlogPNone
SynonymsCHEMBL1360140
SMR000228466
2-[2-(1H-indol-3-yl)vinyl]-1-methyl-5-(1-piperidinylcarbonyl)pyridinium
HMS2646A20
Inchi KeyCCGRILLSWYWEGO-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H23N3O.HI/c1-24-16-18(22(26)25-13-5-2-6-14-25)10-12-19(24)11-9-17-15-23-21-8-4-3-7-20(17)21;/h3-4,7-12,15-16H,2,5-6,13-14H2,1H3;1H
PubChem CID16189307
ChEMBLCHEMBL1360140
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessPartition coefficient log P of this ligand is not available.

Experimental Data

ParameterValueReferenceDatabase source
Potency23109.3 nMPubChem BioAssay data setChEMBL

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