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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	G-protein coupled bile acid receptor 1
Species	Homo sapiens (Human)
Gene	GPBAR1
Synonym	G-protein coupled receptor GPCR19 TGR5 BG37 G protein-coupled bile acid receptor 1 membrane-type receptor for bile acids M-BAR hGPCR19 hBG37 GPCR19 GPBAR1 GPBA receptor GPR131 [ Show all ]
Disease	Type 2 diabetes Metabolic disorders
Length	330
Amino acid sequence	MTPNSTGEVPSPIPKGALGLSLALASLIITANLLLALGIAWDRRLRSPPAGCFFLSLLLAGLLTGLALPTLPGLWNQSRRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYMAVLRPLQPPGSIRLALLLTWAGPLLFASLPALGWNHWTPGANCSSQAIFPAPYLYLEVYGLLLPAVGAAAFLSVRVLATAHRQLQDICRLERAVCRDEPSALARALTWRQARAQAGAMLLFGLCWGPYVATLLLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDQRYTAPWRAAAQRCLQGLWGRASRDSPGPSIAYHPSSQSSVDLDLN
UniProt	Q8TDU6
Protein Data Bank	N/A
GPCR-HGmod model	Q8TDU6
3D structure model	This predicted structure model is from GPCR-EXP Q8TDU6.
BioLiP	N/A
Therapeutic Target Database	T86273
ChEMBL	CHEMBL5409
IUPHAR	37
DrugBank	BE0005788

Ligand

Name	CHEMBL605367
Molecular formula	C20H18Cl2N2O2
IUPAC name	3-(2-chlorophenyl)-N-(4-chlorophenyl)-N,5-diethyl-1,2-oxazole-4-carboxamide
Molecular weight	389.276
Hydrogen bond acceptor	3
Hydrogen bond donor	0
XlogP	5.5
Synonyms	BDBM50415425
Inchi Key	CDFUXZCJVGNQRP-UHFFFAOYSA-N
Inchi ID	InChI=1S/C20H18Cl2N2O2/c1-3-17-18(19(23-26-17)15-7-5-6-8-16(15)22)20(25)24(4-2)14-11-9-13(21)10-12-14/h5-12H,3-4H2,1-2H3
PubChem CID	46232696
ChEMBL	CHEMBL605367
IUPHAR	N/A
BindingDB	50415425
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
EC50	10.0 nM	PMID20097073	BindingDB,ChEMBL

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