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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Lutropin-choriogonadotropic hormone receptor
Species	Rattus norvegicus (Rat)
Gene	Lhcgr
Synonym	Luteinizing hormone receptor LSH-R LHR LH/CG-R LH-R LH receptor LGR2 LCGR Choriogonadotropin receptor lutropin-choriogonadotropic hormone receptor [ Show all ]
Disease	N/A for non-human GPCRs
Length	700
Amino acid sequence	MGRRVPALRQLLVLAVLLLKPSQLQSRELSGSRCPEPCDCAPDGALRCPGPRAGLARLSLTYLPVKVIPSQAFRGLNEVVKIEISQSDSLERIEANAFDNLLNLSELLIQNTKNLLYIEPGAFTNLPRLKYLSICNTGIRTLPDVTKISSSEFNFILEICDNLHITTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAFNGTTLISLELKENIYLEKMHSGAFQGATGPSILDISSTKLQALPSHGLESIQTLIALSSYSLKTLPSKEKFTSLLVATLTYPSHCCAFRNLPKKEQNFSFSIFENFSKQCESTVRKADNETLYSAIFEENELSGWDYDYGFCSPKTLQCAPEPDAFNPCEDIMGYAFLRVLIWLINILAIFGNLTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCGAAGFFTVFASELSVYTLTVITLERWHTITYAVQLDQKLRLRHAIPIMLGGWLFSTLIATMPLVGISNYMKVSICLPMDVESTLSQVYILSILILNVVAFVVICACYIRIYFAVQNPELTAPNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKILLVLFYPVNSCANPFLYAIFTKAFQRDFLLLLSRFGCCKRRAELYRRKEFSAYTSNCKNGFPGASKPSQATLKLSTVHCQQPIPPRALTH
UniProt	P16235
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2456
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	GONADORELIN
Molecular formula	C55H75N17O13
IUPAC name	(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[(2S)-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
Molecular weight	1182.31
Hydrogen bond acceptor	15
Hydrogen bond donor	16
XlogP	-2.4
Synonyms	SCHEMBL143114 1092062-05-9 52699-48-6 (Acetate) A1147 GnRH-I HS-2014 Luteinizing hormone-releasing factor 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycyl-L-leucyl-L-arginyl-L-prolylglycinamide 9034-40-6 AKOS030213247 EINECS 251-553-1 Gonadorelin (INN) LH-FSH Releasing Hormone MolPort-006-069-187 pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-GlyNH2 515G092 9066-58-4 BDBM50422274 Glycinamide, 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycyl-L-leucyl-L-arginyl-L-prolyl- Gonadotropin-releasing factor Luliberin UNII-9O7312W37G 33515-09-2 71339-77-0 AC1LCX3Q CHEMBL1007 Gonadoliberin I Human gonadoliberin-i Luteinizing hormone-releasing hormone p-Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 5-oxo-PHWSYGLRPGNH2 9042-18-6 AY 24031 Fertagyl (TN) Gonadorelina LH-Releasing factor Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 51952-41-1 (Hydrochloride) 9O7312W37G CHEBI:5520 Gn-RH Gonadotropin-releasing hormone I Luteinizing hormone releasing hormone human acetate salt (LHRH) XLXSAKCOAKORKW-AQJXLSMYSA-N 38569-05-0 71447-49-9 AKOS015895122 D08027 KS-00002WUR Luteostimulin pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH(2) 9061-55-6 AY-24031 Follicle-stimulating hormone-releasing factor Gonadorelinum LH-Releasing hormone [ Show all ]
Inchi Key	XLXSAKCOAKORKW-AQJXLSMYSA-N
Inchi ID	InChI=1S/C55H75N17O13/c1-29(2)19-38(49(80)67-37(9-5-17-60-55(57)58)54(85)72-18-6-10-43(72)53(84)62-25-44(56)75)66-46(77)26-63-47(78)39(20-30-11-13-33(74)14-12-30)68-52(83)42(27-73)71-50(81)40(21-31-23-61-35-8-4-3-7-34(31)35)69-51(82)41(22-32-24-59-28-64-32)70-48(79)36-15-16-45(76)65-36/h3-4,7-8,11-14,23-24,28-29,36-43,61,73-74H,5-6,9-10,15-22,25-27H2,1-2H3,(H2,56,75)(H,59,64)(H,62,84)(H,63,78)(H,65,76)(H,66,77)(H,67,80)(H,68,83)(H,69,82)(H,70,79)(H,71,81)(H4,57,58,60)/t36-,37-,38-,39-,40-,41-,42-,43-/m0/s1
PubChem CID	638793
ChEMBL	CHEMBL1007
IUPHAR	N/A
BindingDB	50422274
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand has more than 10 hydrogen bond acceptor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1.259 nM	PMID2552116	ChEMBL
pD2	9.27 -	PMID2552116	ChEMBL

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