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GPCR

NameP2Y purinoceptor 1
SpeciesRattus norvegicus (Rat)
GeneP2ry1
SynonymATP receptor
purinergic receptor P2Y
Purinergic receptor
platelet ADP receptor
P2Y1 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length373
Amino acid sequenceMTEVPWSAVPNGTDAAFLAGLGSLWGNSTIASTAAVSSSFRCALIKTGFQFYYLPAVYILVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDVMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAIYVSVLVWLIVVVAISPILFYSGTGIRKNKTVTCYDSTSDEYLRSYFIYSMCTTVAMFCIPLVLILGCYGLIVRALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPEMCDFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEEMTLNILSEFKQNGDTSL
UniProtP49651
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2497
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL2364736
Molecular formulaC11H14N5O13P3S-4
IUPAC name[[[(2R,3S,4R,5R)-5-(6-amino-2-methylsulfanylpurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] phosphate
Molecular weight549.236
Hydrogen bond acceptor18
Hydrogen bond donor3
XlogP-5.2
SynonymsBDBM50422408
NCGC00024975-03
2-Methylthioadenosine triphosphate tetrasodium
NCGC00024975-02
Inchi KeyXNOBOKJVOTYSJV-KQYNXXCUSA-J
Inchi IDInChI=1S/C11H18N5O13P3S/c1-33-11-14-8(12)5-9(15-11)16(3-13-5)10-7(18)6(17)4(27-10)2-26-31(22,23)29-32(24,25)28-30(19,20)21/h3-4,6-7,10,17-18H,2H2,1H3,(H,22,23)(H,24,25)(H2,12,14,15)(H2,19,20,21)/p-4/t4-,6-,7-,10-/m1/s1
PubChem CID23279499
ChEMBLN/A
IUPHARN/A
BindingDB50422408
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
EC504.5 nMPMID12431066BindingDB

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